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    skr-9 Skp1-related protein [ Caenorhabditis elegans ]

    Gene ID: 178494, updated on 9-Dec-2024

    Summary

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    Official Symbol
    skr-9
    Official Full Name
    Skp1-related protein
    Primary source
    WormBase:WBGene00004815
    Locus tag
    CELE_C52D10.7
    See related
    AllianceGenome:WB:WBGene00004815
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cullin family protein binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm and nucleus. Is expressed in intestine. Orthologous to human SKP1 (S-phase kinase associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See skr-9 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_003282.8 (17163573..17164157)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Skp1-related protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis elegans Skp1-related gene family: diverse functions in cell proliferation, morphogenesis, and meiosis. Nayak S, et al. Curr Biol, 2002 Feb 19. PMID 11864567
    2. Multiple Skp1-related proteins in Caenorhabditis elegans: diverse patterns of interaction with Cullins and F-box proteins. Yamanaka A, et al. Curr Biol, 2002 Feb 19. PMID 11864566
    3. DRE-1: an evolutionarily conserved F box protein that regulates C. elegans developmental age. Fielenbach N, et al. Dev Cell, 2007 Mar. PMID 17336909
    4. Proteasomal regulation of the hypoxic response modulates aging in C. elegans. Mehta R, et al. Science, 2009 May 29. PMID 19372390, Free PMC Article
    5. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Skp1-related protein
    NP_503043.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      17163573..17164157
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070642.6 → NP_503043.1  Skp1-related protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503043.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFA9
      Conserved Domains (2) summary
      smart00512
      Location:20 → 129
      Skp1; Found in Skp1 protein family
      pfam01466
      Location:103 → 161
      Skp1; Skp1 family, dimerization domain
    Nucleotide Protein
    Heading Accession and Version

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