U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    pcaf-1 Histone acetyltransferase GCN5 [ Caenorhabditis elegans ]

    Gene ID: 171920, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    pcaf-1
    Official Full Name
    Histone acetyltransferase GCN5
    Primary source
    WormBase:WBGene00021636
    Locus tag
    CELE_Y47G6A.6
    See related
    AllianceGenome:WB:WBGene00021636
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable histone H3 acetyltransferase activity. Predicted to be involved in chromatin remodeling and positive regulation of transcription by RNA polymerase II. Predicted to be located in centrosome and nucleus. Predicted to be part of ATAC complex. Orthologous to several human genes including KAT2A (lysine acetyltransferase 2A). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See pcaf-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    11
    Sequence:
    Chromosome: I; NC_003279.8 (3516450..3523418)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Sugar phosphate transporter domain-containing protein Neighboring gene ncRNA Neighboring gene Golgi phosphoprotein 3 homolog sauron Neighboring gene Peptidase M14 carboxypeptidase A domain-containing protein;ShKT domain-containing protein Neighboring gene 40S ribosomal protein S19-binding protein 1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Differential chromatin marking of introns and expressed exons by H3K36me3. Kolasinska-Zwierz P, et al. Nat Genet, 2009 Mar. PMID 19182803, Free PMC Article
    2. Double bromodomain protein BET-1 and MYST HATs establish and maintain stable cell fates in C. elegans. Shibata Y, et al. Development, 2010 Apr. PMID 20181741
    3. HAT activity is essential for CBP-1-dependent transcription and differentiation in Caenorhabditis elegans. Victor M, et al. EMBO Rep, 2002 Jan. PMID 11751575, Free PMC Article
    4. A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling. Ceol CJ, et al. Dev Cell, 2004 Apr. PMID 15068795
    5. The candidate MAP kinase phosphorylation substrate DPL-1 (DP) promotes expression of the MAP kinase phosphatase LIP-1 in C. elegans germ cells. Lin B, et al. Dev Biol, 2008 Apr 1. PMID 18304523, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3 acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K9 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ATAC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Histone acetyltransferase GCN5
    NP_491173.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3516450..3523418
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058772.8 → NP_491173.1  Histone acetyltransferase GCN5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491173.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N3S7
      Conserved Domains (4) summary
      cd05509
      Location:650 → 748
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5076
      Location:408 → 735
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam00583
      Location:476 → 544
      Acetyltransf_1; Acetyltransferase (GNAT) family
      pfam06466
      Location:9 → 247
      PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous