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    mlk-1 Mitogen-activated protein kinase kinase kinase mlk-1 [ Caenorhabditis elegans ]

    Gene ID: 178895, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mlk-1
    Official Full Name
    Mitogen-activated protein kinase kinase kinase mlk-1
    Primary source
    WormBase:WBGene00003374
    Locus tag
    CELE_K11D12.10
    See related
    AllianceGenome:WB:WBGene00003374
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein kinase C binding activity; receptor tyrosine kinase binding activity; and scaffold protein binding activity. Involved in several processes, including MAPK cascade; determination of adult lifespan; and positive regulation of axon extension involved in regeneration. Predicted to be active in cytoplasm. Is expressed in body wall musculature; hypodermis; intestine; neurons; and pharynx. Orthologous to several human genes including MAP3K21 (mitogen-activated protein kinase kinase kinase 21) and MAP3K9 (mitogen-activated protein kinase kinase kinase 9). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mlk-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    17
    Sequence:
    Chromosome: V; NC_003283.11 (5056378..5064811, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene C2H2-type domain-containing protein Neighboring gene Coexpressed With Polycystins Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Copper transport protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional Recovery Associated with Dendrite Regeneration in PVD Neuron of Caenorhabditis elegans. Brar HK, et al. eNeuro, 2024 May. PMID 38548333, Free PMC Article
    2. Neuronal development in Caenorhabditis elegans is regulated by inhibition of an MLK MAP kinase pathway. Baker ST, et al. Genetics, 2015 Jan. PMID 25339611, Free PMC Article
    3. The growth factor SVH-1 regulates axon regeneration in C. elegans via the JNK MAPK cascade. Li C, et al. Nat Neurosci, 2012 Mar 4. PMID 22388962
    4. Caffeine-induced food-avoidance behavior is mediated by neuroendocrine signals in Caenorhabditis elegans. Min H, et al. BMB Rep, 2017 Jan. PMID 27697105, Free PMC Article
    5. The C. elegans Discoidin Domain Receptor DDR-2 Modulates the Met-like RTK-JNK Signaling Pathway in Axon Regeneration. Hisamoto N, et al. PLoS Genet, 2016 Dec. PMID 27984580, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase C binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables receptor tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon regeneration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in p38MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of axon extension involved in regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of axon regeneration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of axon regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to copper ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to starvation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Mitogen-activated protein kinase kinase kinase mlk-1
    NP_001300151.1
    • Confirmed by transcript evidence
    NP_001300152.1
    • Confirmed by transcript evidence
    NP_741536.1
    • Confirmed by transcript evidence
    NP_741537.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      5056378..5064811 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001313222.3 → NP_001300151.1  Mitogen-activated protein kinase kinase kinase mlk-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0K3AS83, A0A0K3AV08, H2KYR3, Q8T7Z0
      Conserved Domains (3) summary
      smart00221
      Location:153 → 450
      STYKc; Protein kinase; unclassified specificity
      cl17036
      Location:75 → 124
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:156 → 446
      PKc_like; Protein Kinases, catalytic domain

    2. NM_171928.7 → NP_741537.1  Mitogen-activated protein kinase kinase kinase mlk-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741537.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0K3AV08
      Conserved Domains (3) summary
      smart00221
      Location:153 → 450
      STYKc; Protein kinase; unclassified specificity
      cl17036
      Location:75 → 124
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:156 → 446
      PKc_like; Protein Kinases, catalytic domain

    3. NM_171456.8 → NP_741536.1  Mitogen-activated protein kinase kinase kinase mlk-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741536.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0K3AV08
      Conserved Domains (3) summary
      smart00221
      Location:153 → 450
      STYKc; Protein kinase; unclassified specificity
      cl17036
      Location:75 → 124
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:156 → 446
      PKc_like; Protein Kinases, catalytic domain

    4. NM_001313223.3 → NP_001300152.1  Mitogen-activated protein kinase kinase kinase mlk-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0K3AV08
      Conserved Domains (3) summary
      smart00221
      Location:153 → 450
      STYKc; Protein kinase; unclassified specificity
      cl17036
      Location:75 → 124
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:156 → 446
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0K3AV08.1

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