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    nape-1 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D 1 [ Caenorhabditis elegans ]

    Gene ID: 177137, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nape-1
    Official Full Name
    N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D 1
    Primary source
    WormBase:WBGene00021371
    Locus tag
    CELE_Y37E11AR.4
    See related
    AllianceGenome:WB:WBGene00021371
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables N-acylphosphatidylethanolamine-specific phospholipase D activity. Involved in N-acylethanolamine metabolic process. Located in neuronal cell body. Is expressed in nervous system; pharynx; and vulval muscle. Orthologous to human NAPEPLD (N-acyl phosphatidylethanolamine phospholipase D). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nape-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (3739520..3740880, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D 2 Neighboring gene ncRNA Neighboring gene E3 ubiquitin-protein ligase siah-1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Endocannabinoid signaling regulates regenerative axon navigation in Caenorhabditis elegans via the GPCRs NPR-19 and NPR-32. Pastuhov SI, et al. Genes Cells, 2016 Jul. PMID 27193416
    2. Characterization of N-acyl phosphatidylethanolamine-specific phospholipase-D isoforms in the nematode Caenorhabditis elegans. Harrison N, et al. PLoS One, 2014. PMID 25423491, Free PMC Article
    3. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables N-acylphosphatidylethanolamine-specific phospholipase D activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acylphosphatidylethanolamine-specific phospholipase D activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N-acylphosphatidylethanolamine-specific phospholipase D activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-acylethanolamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-acylethanolamine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in N-acylphosphatidylethanolamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D 1
    NP_500408.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      3739520..3740880 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068007.5 → NP_500408.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500408.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q965X7
      Conserved Domains (1) summary
      cl23716
      Location:88 → 281
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q965X7.1

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