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    sac-2 Inositol phosphatase domain-containing protein;SAC domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173236, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sac-2
    Official Full Name
    Inositol phosphatase domain-containing protein;SAC domain-containing protein
    Primary source
    WormBase:WBGene00012353
    Locus tag
    CELE_W09C5.7
    See related
    AllianceGenome:WB:WBGene00012353
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphatidylinositol-4-phosphate phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation and regulation of endocytic recycling. Predicted to be active in clathrin-coated endocytic vesicle and early endosome. Orthologous to human INPP5F (inositol polyphosphate-5-phosphatase F). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sac-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (13654009..13658167)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Large ribosomal subunit protein eL31 Neighboring gene Cytochrome c oxidase subunit 4 Neighboring gene pseudo Neighboring gene Leucine Rich repeat-containing domain protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9. Yang S, et al. Neuron, 2022 Mar 2. PMID 35065714, Free PMC Article
    2. The conserved transmembrane protein TMEM-39 coordinates with COPII to promote collagen secretion and regulate ER stress response. Zhang Z, et al. PLoS Genet, 2021 Feb. PMID 33524011, Free PMC Article
    3. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-4-phosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylinositol dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in clathrin-coated endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Inositol phosphatase domain-containing protein;SAC domain-containing protein
    NP_001252206.1
    • Confirmed by transcript evidence
    NP_001252208.1
    • Confirmed by transcript evidence
    NP_001364672.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      13654009..13658167
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001265277.2 → NP_001252206.1  SAC domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001252206.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U330
      Conserved Domains (2) summary
      COG5329
      Location:25 → 520
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      pfam12456
      Location:549 → 615
      hSac2; Inositol phosphatase

    2. NM_001377672.2 → NP_001364672.1  SAC domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      E3W752
      Conserved Domains (2) summary
      COG5329
      Location:2 → 141
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      pfam12456
      Location:170 → 236
      hSac2; Inositol phosphatase

    3. NM_001265279.3 → NP_001252208.1  Inositol phosphatase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001252208.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E3W753
      Conserved Domains (1) summary
      pfam12456
      Location:4 → 73
      hSac2; Inositol phosphatase
    Nucleotide Protein
    Heading Accession and Version

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