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    rlbp-1 Rho-GAP domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172530, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rlbp-1
    Official Full Name
    Rho-GAP domain-containing protein
    Primary source
    WormBase:WBGene00011970
    Locus tag
    CELE_T23G11.5
    See related
    AllianceGenome:WB:WBGene00011970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in receptor-mediated endocytosis and small GTPase-mediated signal transduction. Human ortholog(s) of this gene implicated in pancreatic adenocarcinoma. Orthologous to human RALBP1 (ralA binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rlbp-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (7683341..7694210)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Golgin-84 Neighboring gene HAUS6_N domain-containing protein;Vacuolar protein sorting-associated protein VTA1 homolog Neighboring gene eLRR (extracellular Leucine-Rich Repeat) ONly Neighboring gene Hepatocellular carcinoma-associated antigen 59 Neighboring gene Female germline-specific tumor suppressor gld-1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RAL-1 signaling regulates lipid composition in C. elegans. Wu Y, et al. MicroPubl Biol, 2024. PMID 38454952, Free PMC Article
    2. RAP-1 and the RAL-1/exocyst pathway coordinate hypodermal cell organization in Caenorhabditis elegans. Frische EW, et al. EMBO J, 2007 Dec 12. PMID 17989692, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in receptor-mediated endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small GTPase-mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rho-GAP domain-containing protein
    NP_001250565.1
    • Confirmed by transcript evidence
    NP_001254005.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7683341..7694210
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267076.2 → NP_001254005.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254005.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XVI0
      Conserved Domains (2) summary
      smart00324
      Location:70 → 209
      RhoGAP; GTPase-activator protein for Rho-like GTPases
      PLN02768
      Location:258 → 325
      PLN02768; AMP deaminase

    2. NM_001263636.3 → NP_001250565.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001250565.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E2JL05
    Nucleotide Protein
    Heading Accession and Version

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