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    cpt-3 Choline/carnitine acyltransferase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 190055, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cpt-3
    Official Full Name
    Choline/carnitine acyltransferase domain-containing protein
    Primary source
    WormBase:WBGene00021703
    Locus tag
    CELE_Y48G9A.10
    See related
    AllianceGenome:WB:WBGene00021703
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable carnitine O-palmitoyltransferase activity. Predicted to be involved in carnitine metabolic process and fatty acid metabolic process. Predicted to be located in membrane. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cpt-3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (2082819..2088314)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Tyrosine-protein phosphatase domain-containing protein Neighboring gene pseudo Neighboring gene Protein-tyrosine phosphatase Neighboring gene PIPK domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans. Taubert S, et al. Genes Dev, 2006 May 1. PMID 16651656, Free PMC Article
    2. IRE-1 and HSP-4 contribute to energy homeostasis via fasting-induced lipases in C. elegans. Jo H, et al. Cell Metab, 2009 May. PMID 19416714
    3. Intracellular lipid surveillance by small G protein geranylgeranylation. Watterson A, et al. Nature, 2022 May. PMID 35585236, Free PMC Article
    4. Evolutionary analysis of the carnitine- and choline acyltransferases suggests distinct evolution of CPT2 versus CPT1 and related variants. van der Hoek MD, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2018 Aug. PMID 29730527
    5. Fatty acid desaturation and the regulation of adiposity in Caenorhabditis elegans. Brock TJ, et al. Genetics, 2007 Jun. PMID 17435249, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carnitine O-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in carnitine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Choline/carnitine acyltransferase domain-containing protein
    NP_497498.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      2082819..2088314
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065097.5 → NP_497498.2  Choline/carnitine acyltransferase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497498.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N3N3
      Conserved Domains (1) summary
      pfam00755
      Location:128 → 716
      Carn_acyltransf; Choline/Carnitine o-acyltransferase
    Nucleotide Protein
    Heading Accession and Version

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