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    csn-3 COP9 signalosome complex subunit 3 [ Caenorhabditis elegans ]

    Gene ID: 176834, updated on 9-Dec-2024

    Summary

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    Official Symbol
    csn-3
    Official Full Name
    COP9 signalosome complex subunit 3
    Primary source
    WormBase:WBGene00000815
    Locus tag
    CELE_Y38C1AA.2
    See related
    AllianceGenome:WB:WBGene00000815
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in establishment of mitotic spindle localization; mitotic cytokinesis; and ubiquitin-dependent protein catabolic process. Part of COP9 signalosome. Orthologous to human COPS3 (COP9 signalosome subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See csn-3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (194742..202586)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene T-cell defective protein 2 Neighboring gene nicotinamidase Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene GTP cyclohydrolase 1 feedback regulatory protein Neighboring gene Cytochrome Oxidase Assembly subunits

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans. Pintard L, et al. Curr Biol, 2003 May 27. PMID 12781129
    2. CIF-1, a shared subunit of the COP9/signalosome and eukaryotic initiation factor 3 complexes, regulates MEL-26 levels in the Caenorhabditis elegans embryo. Luke-Glaser S, et al. Mol Cell Biol, 2007 Jun. PMID 17403899, Free PMC Article
    3. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
    4. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
    5. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of mitotic spindle localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COP9 signalosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of COP9 signalosome IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    COP9 signalosome complex subunit 3
    NP_499878.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      194742..202586
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067477.9 → NP_499878.3  COP9 signalosome complex subunit 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499878.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9N425
      Conserved Domains (1) summary
      pfam01399
      Location:338 → 432
      PCI; PCI domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9N425.4

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