npr-22 Neuropeptide receptor 22 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: npr-22
Official Full Name: Neuropeptide receptor 22
Primary source: WormBase:WBGene00022004
Locus tag: CELE_Y59H11AL.1
See related: AllianceGenome:WB:WBGene00022004
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables neuropeptide receptor activity. Involved in several processes, including determination of adult lifespan; neuropeptide signaling pathway; and positive regulation of egg-laying behavior. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in head muscle; intestine; neurons; and pharyngeal muscle cell. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See npr-22 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (8559432..8563161)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study reports that the FLP-7 neuropeptide and its cognate receptor, NPR-22, function as the ligand-receptor pair that defines the neuroendocrine axis of serotonergic body fat loss in Caenorhabditis elegans.
Title: A tachykinin-like neuroendocrine signalling axis couples central serotonin action and nutrient sensing with peripheral lipid metabolism.
Two novel Caenorhabditis elegans neuropeptides, LURY-1-1 and LURY-1-2, have been identified as endogenous ligands for the neuropeptide receptor-22 (NPR-22).
Title: Luqin-like RYamide peptides regulate food-evoked responses in C. elegans.
the orphan receptor encoded by the Y59H11AL.1 gene is activated by several C. elegans neuropeptides, including SPMERSAMVRFamide
Title: FMRFamide related peptide ligands activate the Caenorhabditis elegans orphan GPCR Y59H11AL.1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables neuropeptide receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in determination of adult lifespan	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of feeding behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of locomotion	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of egg-laying behavior	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Neuropeptide receptor 22

NP_001023540.1

Confirmed by transcript evidence

NP_001023541.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

8559432..8563161

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001028370.5 → NP_001023541.1 Neuropeptide receptor 22 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023541.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q59E83, Q9N324

Conserved Domains (1) summary

cd15392
Location:51 → 347

7tmA_PR4-like; neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001028369.4 → NP_001023540.1 Neuropeptide receptor 22 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023540.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q59E83

Conserved Domains (2) summary

pfam00001
Location:67 → 336

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:61 → 195

7tm_4; Olfactory receptor