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    ifta-2 Intraflagellar transport associated protein 2 [ Caenorhabditis elegans ]

    Gene ID: 189055, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ifta-2
    Official Full Name
    Intraflagellar transport associated protein 2
    Primary source
    WormBase:WBGene00012132
    Locus tag
    CELE_T28F3.6
    See related
    AllianceGenome:WB:WBGene00012132
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activity. Involved in several processes, including dauer larval development; determination of adult lifespan; and insulin-like growth factor receptor signaling pathway. Located in axoneme and ciliary base. Is expressed in amphid neurons and phasmid neurons. Orthologous to human IFT22 (intraflagellar transport 22). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ifta-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (17300809..17302033, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Zinc transporter zipt-7.1 Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene acetyl-CoA carboxylase Neighboring gene pseudo Neighboring gene EGF-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DYF-5/MAK-dependent phosphorylation promotes ciliary tubulin unloading. Jiang X, et al. Proc Natl Acad Sci U S A, 2022 Aug 23. PMID 35969738, Free PMC Article
    2. Reconstitution reveals motor activation for intraflagellar transport. Mohamed MAA, et al. Nature, 2018 May. PMID 29743676, Free PMC Article
    3. Functional genomics of intraflagellar transport-associated proteins in C. elegans. Inglis PN, et al. Methods Cell Biol, 2009. PMID 20409822
    4. IFTA-2 is a conserved cilia protein involved in pathways regulating longevity and dauer formation in Caenorhabditis elegans. Schafer JC, et al. J Cell Sci, 2006 Oct 1. PMID 16968739
    5. Dynein-Driven Retrograde Intraflagellar Transport Is Triphasic in C. elegans Sensory Cilia. Yi P, et al. Curr Biol, 2017 May 22. PMID 28479320

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IFTA-2 is not a ciliogenic protein but rather is a regulator of specific cilia signaling activities.
      Title: IFTA-2 is a conserved cilia protein involved in pathways regulating longevity and dauer formation in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in dauer larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in insulin-like growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axoneme IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary base IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Intraflagellar transport associated protein 2
    NP_503073.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      17300809..17302033 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070672.4 → NP_503073.1  Intraflagellar transport associated protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503073.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XUC2
      Conserved Domains (2) summary
      COG1100
      Location:26 → 174
      Gem1; GTPase SAR1 family domain [General function prediction only]
      cl21455
      Location:30 → 177
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XUC2.1

    Gene LinkOut

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