sun-1 Sun domain-containing protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sun-1
Official Full Name: Sun domain-containing protein 1
Primary source: WormBase:WBGene00006311
Locus tag: CELE_F57B1.2
See related: AllianceGenome:WB:WBGene00006311
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein-membrane adaptor activity. Involved in several processes, including centrosome localization; embryo development; and regulation of centrosome duplication. Located in nuclear envelope. Is expressed in several structures, including AB; C; D; E; and germ line. Human ortholog(s) of this gene implicated in spermatogenic failure 16. Orthologous to human SUN5 (Sad1 and UNC84 domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sun-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 5

Sequence:: Chromosome: V; NC_003283.11 (13191700..13193538, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Coiled-coil domains of SUN-1 are required for oligomerization and retention of the protein in the nuclear envelope, especially at later stages of female gametogenesis.
Title: Nuclear Envelope Retention of LINC Complexes Is Promoted by SUN-1 Oligomerization in the Caenorhabditis elegans Germ Line.
POT-1 has a role in anchoring telomeres through SUN-1 at the nuclear periphery.
Title: The shelterin protein POT-1 anchors Caenorhabditis elegans telomeres through SUN-1 at the nuclear periphery.
This suggests that SUN-1 phosphorylation is critical to delaying meiosis in response to perturbed synapsis. SUN-1 may be an integral part of a checkpoint system to monitor establishment of the obligate crossover
Title: Matefin/SUN-1 phosphorylation is part of a surveillance mechanism to coordinate chromosome synapsis and recombination with meiotic progression and chromosome movement.
The dynamics of matefin/SUN-1 aggregates remained unchanged throughout leptonene/zygotene, despite the progression of pairing.
Title: Leptotene/zygotene chromosome movement via the SUN/KASH protein bridge in Caenorhabditis elegans.
[REVIEW]functions of these KASH/SUN protein pairs across spatial and temporal C. elegans development
Title: Movers and shakers or anchored: Caenorhabditis elegans nuclei achieve it with KASH/SUN.
Data show that ZYG-12 is immobile at the outer nuclear membrane and that SUN-1 is sufficient to localize ZYG-12 in cells.
Title: SUN-1 and ZYG-12, mediators of centrosome-nucleus attachment, are a functional SUN/KASH pair in Caenorhabditis elegans.
Data suggest that the properties of the nuclear envelope are altered during the time window when homologs are sorted and Matefin/SUN-1 aggregates form, thereby controling the movement, homologous pairing and interhomolog recombination of chromosomes.
Title: Meiotic chromosome homology search involves modifications of the nuclear envelope protein Matefin/SUN-1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F57B1.1 (e-PCR)
- UniSTS:316828

F57B1.2 (e-PCR)
- UniSTS:321522

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-membrane adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in centrosome localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of centrosome duplication	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of meiotic nuclear membrane microtubule tethering complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Sun domain-containing protein 1

NP_506281.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

13191700..13193538 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073880.6 → NP_506281.1 Sun domain-containing protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506281.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q20924

Conserved Domains (1) summary

pfam07738
Location:302 → 442

Sad1_UNC; Sad1 / UNC-like C-terminal