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    ooc-3 Chloride channel CLIC-like protein 1 [ Caenorhabditis elegans ]

    Gene ID: 174759, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ooc-3
    Official Full Name
    Chloride channel CLIC-like protein 1
    Primary source
    WormBase:WBGene00003868
    Locus tag
    CELE_B0334.11
    See related
    AllianceGenome:WB:WBGene00003868
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable chloride channel activity. Involved in embryo development; establishment of mitotic spindle orientation; and protein localization. Located in endoplasmic reticulum. Is expressed in P0. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ooc-3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    8
    Sequence:
    Chromosome: II; NC_003280.10 (11493159..11495321, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene FMRF-Like Peptide Neighboring gene 2-hydroxyacyl-CoA lyase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene PRELI/MSF1 domain-containing protein Neighboring gene Membrane magnesium transporter Neighboring gene Phytoene synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. OOC-3, a novel putative transmembrane protein required for establishment of cortical domains and spindle orientation in the P(1) blastomere of C. elegans embryos. Pichler S, et al. Development, 2000 May. PMID 10769231
    2. The Caenorhabditis elegans polarity gene ooc-5 encodes a Torsin-related protein of the AAA ATPase superfamily. Basham SE, et al. Development, 2001 Nov. PMID 11714689
    3. Mutations in ooc-5 and ooc-3 disrupt oocyte formation and the reestablishment of asymmetric PAR protein localization in two-cell Caenorhabditis elegans embryos. Basham SE, et al. Dev Biol, 1999 Nov 15. PMID 10545235
    4. Maternal-effect lethal mutations on linkage group II of Caenorhabditis elegans. Kemphues KJ, et al. Genetics, 1988 Dec. PMID 3224814, Free PMC Article
    5. RAB-11 permissively regulates spindle alignment by modulating metaphase microtubule dynamics in Caenorhabditis elegans early embryos. Zhang H, et al. Mol Biol Cell, 2008 Jun. PMID 18385514, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of mitotic spindle orientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment or maintenance of cell polarity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Chloride channel CLIC-like protein 1
    NP_496456.1
    • Confirmed by transcript evidence
    NP_871910.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11493159..11495321 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064055.4 → NP_496456.1  Chloride channel CLIC-like protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496456.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XVW6

    2. NM_182110.3 → NP_871910.1  Chloride channel CLIC-like protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871910.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I132
    Nucleotide Protein
    Heading Accession and Version

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