kvs-1 BTB domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: kvs-1
Official Full Name: BTB domain-containing protein
Primary source: WormBase:WBGene00002242
Locus tag: CELE_C53C9.3
See related: AllianceGenome:WB:WBGene00002242
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables voltage-gated potassium channel activity. Involved in several processes, including forward locomotion; hyperosmotic response; and mechanosensory behavior. Part of voltage-gated potassium channel complex. Is expressed in PDA; amphid neurons; anal depressor muscle; sperm; and ventral cord neurons. Human ortholog(s) of this gene implicated in alcohol dependence; developmental and epileptic encephalopathy 26; and epilepsy. Orthologous to several human genes including KCNF1 (potassium voltage-gated channel modifier subfamily F member 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See kvs-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 15

Sequence:: Chromosome: X; NC_003284.9 (7690498..7707131, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Together, these findings establish a pivotal role for ROS-mediated oxidation of voltage-gated K(+) channels in sensorial decline during aging in invertebrates.
Title: Oxidation of a potassium channel causes progressive sensory function loss during aging.
KVS-1 is the first example of a novel type of Kv channel simultaneously possessing an N-inactivating ball preceded by an N inactivation regulatory domain (NIRD) that acts to slow down inactivation through steric mechanisms
Title: A new mode of regulation of N-type inactivation in a Caenorhabditis elegans voltage-gated potassium channel.
three different MPS subunits combine with KVS-1 to form both binary (MPS-1.KVS-1) and ternary (MPS-2.MPS-3.KVS-1) complexes in chemosensory neurons
Title: A family of K+ channel ancillary subunits regulate taste sensitivity in Caenorhabditis elegans.
the cloning and functional characterization of a MiRP beta-subunit, MPS-1, and of a voltage-gated pore-forming potassium subunit, KVS-1 [MPS-1] [KVS-1]
Title: A potassium channel-MiRP complex controls neurosensory function in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C53C9.3 (e-PCR)
- UniSTS:320251

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables potassium channel activity	IEA Inferred from Electronic Annotation more info
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in forward locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hyperosmotic response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mechanosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in regulation of chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: BTB domain-containing protein

NP_001024489.1

Confirmed by transcript evidence

NP_001024490.1

Partially confirmed by transcript evidence

NP_001360715.1

Confirmed by transcript evidence

NP_001361979.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

7690498..7707131 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001373368.2 → NP_001360715.1 BTB domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A4V0INI0, Q86GI9

Conserved Domains (2) summary

cd18317
Location:73 → 163

BTB_POZ_Kv; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels

pfam00520
Location:276 → 475

Ion_trans; Ion transport protein
NM_001029318.5 → NP_001024489.1 BTB domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024489.1

Status: REVIEWED

UniProtKB/TrEMBL

H2KZE7, Q86GI9

Conserved Domains (3) summary

pfam00520
Location:267 → 466

Ion_trans; Ion transport protein

pfam07885
Location:387 → 468

Ion_trans_2; Ion channel

cl02518
Location:73 → 172

BTB; BTB/POZ domain
NM_001375071.1 → NP_001361979.1 BTB domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

H2KZE8, Q6YGZ6

Conserved Domains (2) summary

cd18317
Location:73 → 163

BTB_POZ_Kv; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels

pfam00520
Location:267 → 466

Ion_trans; Ion transport protein
NM_001029319.4 → NP_001024490.1 BTB domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024490.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7JPF0, Q86GI9

Conserved Domains (3) summary

pfam00520
Location:272 → 471

Ion_trans; Ion transport protein

pfam07885
Location:392 → 473

Ion_trans_2; Ion channel

cl02518
Location:78 → 177

BTB; BTB/POZ domain