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    him-10 Kinetochore protein Nuf2 homolog [ Caenorhabditis elegans ]

    Gene ID: 175813, updated on 9-Dec-2024

    Summary

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    Official Symbol
    him-10
    Official Full Name
    Kinetochore protein Nuf2 homolog
    Primary source
    WormBase:WBGene00001869
    Locus tag
    CELE_R12B2.4
    See related
    AllianceGenome:WB:WBGene00001869
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable microtubule binding activity and structural molecule activity. Involved in kinetochore organization; mitotic spindle organization; and nuclear chromosome segregation. Located in kinetochore. Part of Ndc80 complex. Human ortholog(s) of this gene implicated in castration-resistant prostate carcinoma and pancreatic cancer. Orthologous to human NUF2 (NUF2 component of NDC80 kinetochore complex). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See him-10 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (5803260..5805112)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene DNA polymerase Neighboring gene ncRNA Neighboring gene DNA polymerase theta Neighboring gene Homeobox protein ceh-10 Neighboring gene Ras-associating domain-containing protein Neighboring gene Golgin-45

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HIM-10 is required for kinetochore structure and function on Caenorhabditis elegans holocentric chromosomes. Howe M, et al. J Cell Biol, 2001 Jun 11. PMID 11402066, Free PMC Article
    2. trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase. Meier B, et al. PLoS Genet, 2006 Feb. PMID 16477310, Free PMC Article
    3. CentTracker: a trainable, machine-learning-based tool for large-scale analyses of Caenorhabditis elegans germline stem cell mitosis. Zellag RM, et al. Mol Biol Cell, 2021 Apr 19. PMID 33502892, Free PMC Article
    4. Structural comparison of the Caenorhabditis elegans and human Ndc80 complexes bound to microtubules reveals distinct binding behavior. Wilson-Kubalek EM, et al. Mol Biol Cell, 2016 Apr 15. PMID 26941333, Free PMC Article
    5. C. elegans condensin promotes mitotic chromosome architecture, centromere organization, and sister chromatid segregation during mitosis and meiosis. Hagstrom KA, et al. Genes Dev, 2002 Mar 15. PMID 11914278, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural molecule activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in attachment of mitotic spindle microtubules to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in attachment of spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in kinetochore organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in kinetochore organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ndc80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ndc80 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Ndc80 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Kinetochore protein Nuf2 homolog
    NP_498253.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5803260..5805112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065852.6 → NP_498253.1  Kinetochore protein Nuf2 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498253.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21952
      Conserved Domains (2) summary
      pfam00901
      Location:261 → 429
      Orbi_VP5; Orbivirus outer capsid protein VP5
      pfam03800
      Location:28 → 144
      Nuf2; Nuf2 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21952.1

    Gene LinkOut

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    Chemical Information
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