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    dnj-7 J domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180983, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dnj-7
    Official Full Name
    J domain-containing protein
    Primary source
    WormBase:WBGene00001025
    Locus tag
    CELE_C55B6.2
    See related
    AllianceGenome:WB:WBGene00001025
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable misfolded protein binding activity; protein kinase inhibitor activity; and protein-folding chaperone binding activity. Involved in PERK-mediated unfolded protein response. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Is expressed in body wall musculature; head; pharynx; and reproductive system. Orthologous to human DNAJC3 (DnaJ heat shock protein family (Hsp40) member C3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dnj-7 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    10
    Sequence:
    Chromosome: X; NC_003284.9 (7194564..7198291)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene TDP43_N domain-containing protein Neighboring gene Lipase Neighboring gene ncRNA Neighboring gene Carbohydrate kinase FGGY C-terminal domain-containing protein;Glycerol kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload. Oyadomari S, et al. Cell, 2006 Aug 25. PMID 16923392
    2. Compensatory regulation among ER chaperones in C. elegans. Kapulkin WJ, et al. FEBS Lett, 2005 Jun 6. PMID 15907843
    3. GTPase-mediated regulation of the unfolded protein response in Caenorhabditis elegans is dependent on the AAA+ ATPase CDC-48. Caruso ME, et al. Mol Cell Biol, 2008 Jul. PMID 18458060, Free PMC Article
    4. A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response. Urano F, et al. J Cell Biol, 2002 Aug 19. PMID 12186849, Free PMC Article
    5. Development of a transcription-based bioanalytical tool to quantify the toxic potencies of hydrophilic compounds in water using the nematode Caenorhabditis elegans. Karengera A, et al. Ecotoxicol Environ Saf, 2021 Dec 20. PMID 34700171

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables misfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables misfolded protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein kinase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in PERK-mediated unfolded protein response HEP PubMed 
    involved_in endoplasmic reticulum unfolded protein response HEP PubMed 
    involved_in protein folding in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum lumen ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    J domain-containing protein
    NP_509209.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      7194564..7198291
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076808.7 → NP_509209.1  J domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509209.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91189
      Conserved Domains (6) summary
      COG0457
      Location:77 → 360
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      COG0484
      Location:377 → 445
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      sd00006
      Location:29 → 54
      TPR; TPR repeat [structural motif]
      pfam00226
      Location:379 → 444
      DnaJ; DnaJ domain
      pfam00515
      Location:325 → 358
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:29 → 91
      TPR_11; TPR repeat
    Nucleotide Protein
    Heading Accession and Version

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