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    far-7 Fatty Acid/Retinol binding protein [ Caenorhabditis elegans ]

    Gene ID: 173421, updated on 9-Dec-2024

    Summary

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    Official Symbol
    far-7
    Official Full Name
    Fatty Acid/Retinol binding protein
    Primary source
    WormBase:WBGene00001391
    Locus tag
    CELE_K01A2.2
    See related
    AllianceGenome:WB:WBGene00001391
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables oleic acid binding activity. Located in cytoplasm. Is expressed in excretory cell; hypodermis; and in male. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See far-7 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003280.10 (319789..321110)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene MiRP K channel accessory Subunit Neighboring gene MiRP K channel accessory Subunit Neighboring gene ncRNA Neighboring gene CCDC92 domain-containing protein;CCDC92/74 N-terminal domain-containing protein Neighboring gene Beta-sarcoglycan

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Diversity in the structures and ligand-binding sites of nematode fatty acid and retinol-binding proteins revealed by Na-FAR-1 from Necator americanus. Rey-Burusco MF, et al. Biochem J, 2015 Nov 1. PMID 26318523, Free PMC Article
    2. Fatty acid- and retinoid-binding proteins have distinct binding pockets for the two types of cargo. Jordanova R, et al. J Biol Chem, 2009 Dec 18. PMID 19828452, Free PMC Article
    3. The FAR protein family of the nematode Caenorhabditis elegans. Differential lipid binding properties, structural characteristics, and developmental regulation. Garofalo A, et al. J Biol Chem, 2003 Mar 7. PMID 12502713
    4. PQM-1 controls hypoxic survival via regulation of lipid metabolism. Heimbucher T, et al. Nat Commun, 2020 Oct 2. PMID 33009389, Free PMC Article
    5. A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans. Taubert S, et al. Genes Dev, 2006 May 1. PMID 16651656, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oleic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Fatty Acid/Retinol binding protein
    NP_001300557.1
    • Product from WormBase gene class far;
      Confirmed by transcript evidence
    NP_493708.1
    • Product from WormBase gene class far;
      Confirmed by transcript evidence
    NP_871991.2
    • Product from WormBase gene class far;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      319789..321110
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061307.8 → NP_493708.1  Fatty Acid/Retinol binding protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493708.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TZ51
      Conserved Domains (1) summary
      pfam05823
      Location:11 → 136
      Gp-FAR-1; Nematode fatty acid retinoid binding protein (Gp-FAR-1)

    2. NM_182191.6 → NP_871991.2  Fatty Acid/Retinol binding protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KY95
      Conserved Domains (1) summary
      pfam05823
      Location:1 → 88
      Gp-FAR-1; Nematode fatty acid retinoid binding protein (Gp-FAR-1)

    3. NM_001313628.3 → NP_001300557.1  Fatty Acid/Retinol binding protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AWY0

    RNA

    1. NR_132574.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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