U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    R08F11.1 Glycosyl-hydrolase family 116 catalytic region domain-containing protein;Non-lysosomal glucosylceramidase [ Caenorhabditis elegans ]

    Gene ID: 187703, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    R08F11.1
    Official Full Name
    Glycosyl-hydrolase family 116 catalytic region domain-containing protein;Non-lysosomal glucosylceramidase
    Primary source
    WormBase:WBGene00019965
    Locus tag
    CELE_R08F11.1
    See related
    AllianceGenome:WB:WBGene00019965
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable beta-glucosidase activity. Predicted to be involved in carbohydrate metabolic process and glucosylceramide catabolic process. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 46. Orthologous to human GBA2 (glucosylceramidase beta 2). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See R08F11.1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    13
    Sequence:
    Chromosome: V; NC_003283.11 (3777297..3784217, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Dauer Up-Regulated Neighboring gene Methyltransferase domain-containing protein Neighboring gene Methyltransferase domain-containing protein Neighboring gene Cysteine synthase 3 Neighboring gene Peroxidase Neighboring gene pseudo Neighboring gene Serpentine Receptor, class T

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables beta-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucosylceramidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glucosylceramide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Glycosyl-hydrolase family 116 catalytic region domain-containing protein;Non-lysosomal glucosylceramidase
    NP_001317760.1
    • Confirmed by transcript evidence
    NP_001317833.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      3777297..3784217 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001330810.5 → NP_001317760.1  Non-lysosomal glucosylceramidase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01893

    2. NM_001330811.3 → NP_001317833.1  Glycosyl-hydrolase family 116 catalytic region domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A168H9S8
      Conserved Domains (1) summary
      pfam04685
      Location:3 → 319
      DUF608; Glycosyl-hydrolase family 116, catalytic region
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous