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    pro-2 Nucleolar complex protein 2 homolog [ Caenorhabditis elegans ]

    Gene ID: 174598, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pro-2
    Official Full Name
    Nucleolar complex protein 2 homolog
    Primary source
    WormBase:WBGene00007413
    Locus tag
    CELE_C07E3.2
    See related
    AllianceGenome:WB:WBGene00007413
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable histone binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and ribosomal large subunit biogenesis. Predicted to be located in nucleus. Predicted to be part of Noc1p-Noc2p complex and Noc2p-Noc3p complex. Predicted to be active in nucleolus and nucleoplasm. Orthologous to human NOC2L (NOC2 like nucleolar associated transcriptional repressor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pro-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    11
    Sequence:
    Chromosome: II; NC_003280.10 (10339727..10345112, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Intrinsically Disordered Protein, expressed in Pharynx Neighboring gene Activated in Blocked Unfolded protein response;Cysteine rich repeat-containing domain protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Septin and tuftelin-interacting protein 1 homolog;Tuftelin interacting protein N-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ribosome synthesis and MAPK activity modulate ionizing radiation-induced germ cell apoptosis in Caenorhabditis elegans. Eberhard R, et al. PLoS Genet, 2013 Nov. PMID 24278030, Free PMC Article
    2. Alterations in ribosome biogenesis cause specific defects in C. elegans hermaphrodite gonadogenesis. Voutev R, et al. Dev Biol, 2006 Oct 1. PMID 16876152
    3. RSR-2, the Caenorhabditis elegans ortholog of human spliceosomal component SRm300/SRRM2, regulates development by influencing the transcriptional machinery. Fontrodona L, et al. PLoS Genet, 2013 Jun. PMID 23754964, Free PMC Article
    4. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article
    5. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gonadal mesoderm development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Noc1p-Noc2p complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Noc2p-Noc3p complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nucleolar complex protein 2 homolog
    NP_496224.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      10339727..10345112 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063823.6 → NP_496224.2  Nucleolar complex protein 2 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496224.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A7UGI7, O17580, O17971, O18163, Q17785
      Conserved Domains (1) summary
      pfam03715
      Location:328 → 630
      Noc2; Noc2p family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O17580.3

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