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    sqv-2 Beta-1,3-galactosyltransferase sqv-2 [ Caenorhabditis elegans ]

    Gene ID: 173635, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sqv-2
    Official Full Name
    Beta-1,3-galactosyltransferase sqv-2
    Primary source
    WormBase:WBGene00005020
    Locus tag
    CELE_Y110A2AL.14
    See related
    AllianceGenome:WB:WBGene00005020
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables galactosylxylosylprotein 3-beta-galactosyltransferase activity. Involved in several processes, including egg-laying behavior; glycosaminoglycan biosynthetic process; and vulval development. Located in Golgi apparatus. Is expressed in intestine. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome spondylodysplastic type 2 and spondyloepimetaphyseal dysplasia with joint laxity type 1. Orthologous to human B3GALT6 (beta-1,3-galactosyltransferase 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sqv-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (2889116..2894395, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Phosphatidylinositol-glycan biosynthesis class W protein Neighboring gene Peptidyl-prolyl cis-trans isomerase Neighboring gene ncRNA Neighboring gene E2 ubiquitin-conjugating enzyme Neighboring gene E2 ubiquitin-conjugating enzyme;UBIQUITIN_CONJUGAT_2 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis elegans genes sqv-2 and sqv-6, which are required for vulval morphogenesis, encode glycosaminoglycan galactosyltransferase II and xylosyltransferase. Hwang HY, et al. J Biol Chem, 2003 Apr 4. PMID 12584198
    2. sqv mutants of Caenorhabditis elegans are defective in vulval epithelial invagination. Herman T, et al. Proc Natl Acad Sci U S A, 1999 Feb 2. PMID 9927677, Free PMC Article
    3. Mutations that perturb vulval invagination in C. elegans. Herman T, et al. Cold Spring Harb Symp Quant Biol, 1997. PMID 9598369
    4. Recent advances in the structural biology of chondroitin sulfate and dermatan sulfate. Sugahara K, et al. Curr Opin Struct Biol, 2003 Oct. PMID 14568617
    5. C. elegans pharyngeal morphogenesis requires both de novo synthesis of pyrimidines and synthesis of heparan sulfate proteoglycans. Franks DM, et al. Dev Biol, 2006 Aug 15. PMID 16828468

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables galactosylxylosylprotein 3-beta-galactosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables galactosylxylosylprotein 3-beta-galactosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables galactosylxylosylprotein 3-beta-galactosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hexosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chondroitin sulfate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycosaminoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycosaminoglycan biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heparan sulfate proteoglycan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in morphogenesis of an epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Beta-1,3-galactosyltransferase sqv-2
    NP_494394.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      2889116..2894395 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061993.9 → NP_494394.1  Beta-1,3-galactosyltransferase sqv-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494394.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9N491
      Conserved Domains (1) summary
      cl21608
      Location:72 → 259
      Galactosyl_T; Galactosyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9N491.1

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