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    chp-1 Cysteine and histidine-rich domain-containing protein 1 [ Caenorhabditis elegans ]

    Gene ID: 172138, updated on 9-Dec-2024

    Summary

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    Official Symbol
    chp-1
    Official Full Name
    Cysteine and histidine-rich domain-containing protein 1
    Primary source
    WormBase:WBGene00000502
    Locus tag
    CELE_Y110A7A.13
    See related
    AllianceGenome:WB:WBGene00000502
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable zinc ion binding activity. Predicted to be involved in centrosome duplication. Orthologous to human CHORDC1 (cysteine and histidine rich domain containing 1) and ITGB1BP2 (integrin subunit beta 1 binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See chp-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (5103581..5104911, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene Intraflagellar transport protein 20 homolog Neighboring gene V-type proton ATPase subunit B 2 Neighboring gene ncRNA Neighboring gene Proteasome subunit alpha type-4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The CHORD protein CHP-1 regulates EGF receptor trafficking and signaling in C. elegans and in human cells. Haag A, et al. Elife, 2020 Feb 13. PMID 32053105, Free PMC Article
    2. A novel class of eukaryotic zinc-binding proteins is required for disease resistance signaling in barley and development in C. elegans. Shirasu K, et al. Cell, 1999 Nov 12. PMID 10571178
    3. Efficient target-selected mutagenesis in Caenorhabditis elegans: toward a knockout for every gene. Cuppen E, et al. Genome Res, 2007 May. PMID 17416746, Free PMC Article
    4. An integrated strategy to study muscle development and myofilament structure in Caenorhabditis elegans. Meissner B, et al. PLoS Genet, 2009 Jun. PMID 19557190, Free PMC Article
    5. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in centrosome duplication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Cysteine and histidine-rich domain-containing protein 1
    NP_491519.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5103581..5104911 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059118.7 → NP_491519.1  Cysteine and histidine-rich domain-containing protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491519.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EEI8
      Conserved Domains (2) summary
      cd06466
      Location:224 → 307
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      pfam04968
      Location:7 → 68
      CHORD
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EEI8.1

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