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    sacy-1 RNA helicase [ Caenorhabditis elegans ]

    Gene ID: 172413, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sacy-1
    Official Full Name
    RNA helicase
    Primary source
    WormBase:WBGene00019245
    Locus tag
    CELE_H27M09.1
    See related
    AllianceGenome:WB:WBGene00019245
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA helicase activity and mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Located in cytoplasm and nucleus. Is expressed in germ line; hypodermis; intestine; neurons; and somatic cell. Human ortholog(s) of this gene implicated in myeloproliferative neoplasm. Orthologous to human DDX41 (DEAD-box helicase 41). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sacy-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    12
    Sequence:
    Chromosome: I; NC_003279.8 (6851372..6854140)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Synaptonemal complex protein 4 Neighboring gene DNA-directed RNA polymerases I, II, and III subunit RPABC1 Neighboring gene ATP-dependent RNA helicase glh-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Insights into the Involvement of Spliceosomal Mutations in Myelodysplastic Disorders from Analysis of SACY-1/DDX41 in Caenorhabditis elegans. Tsukamoto T, et al. Genetics, 2020 Apr. PMID 32060018, Free PMC Article
    2. RNA helicase SACY-1 is required for longevity caused by various genetic perturbations in Caenorhabditis elegans. Seo M, et al. Cell Cycle, 2016 Jul 17. PMID 27153157, Free PMC Article
    3. Spliceosomal helicases DDX41/SACY-1 and PRP22/MOG-5 both contribute to proofreading against proximal 3' splice site usage. Osterhoudt K, et al. RNA, 2024 Mar 18. PMID 38282418, Free PMC Article
    4. SACY-1 DEAD-Box helicase links the somatic control of oocyte meiotic maturation to the sperm-to-oocyte switch and gamete maintenance in Caenorhabditis elegans. Kim S, et al. Genetics, 2012 Nov. PMID 22887816, Free PMC Article
    5. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Insights into the Involvement of Spliceosomal Mutations in Myelodysplastic Disorders from Analysis of SACY-1/DDX41 in Caenorhabditis elegans.
      Title: Insights into the Involvement of Spliceosomal Mutations in Myelodysplastic Disorders from Analysis of SACY-1/DDX41 in Caenorhabditis elegans.
    2. SACY-1 appears to function as a general longevity factor for various signaling pathways, which is different from the specific function of HEL-1.
      Title: RNA helicase SACY-1 is required for longevity caused by various genetic perturbations in Caenorhabditis elegans.
    3. SACY-1 DEAD-Box helicase links the somatic control of oocyte meiotic maturation to the sperm-to-oocyte switch and gamete maintenance in Caenorhabditis elegans.
      Title: SACY-1 DEAD-Box helicase links the somatic control of oocyte meiotic maturation to the sperm-to-oocyte switch and gamete maintenance in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in P granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA helicase
    NP_491962.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6851372..6854140
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059561.5 → NP_491962.1  RNA helicase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491962.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N5K1
      Conserved Domains (3) summary
      smart00487
      Location:206 → 410
      DEXDc; DEAD-like helicases superfamily
      cd00079
      Location:416 → 544
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:191 → 406
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    Nucleotide Protein
    Heading Accession and Version

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