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    nep-11 Neprilysin-11 [ Caenorhabditis elegans ]

    Gene ID: 173685, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nep-11
    Official Full Name
    Neprilysin-11
    Primary source
    WormBase:WBGene00017557
    Locus tag
    CELE_F18A12.8
    See related
    AllianceGenome:WB:WBGene00017557
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; congestive heart failure; coronary artery disease; essential hypertension; and hypertension. Orthologous to several human genes including ECE1 (endothelin converting enzyme 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nep-11 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    12
    Sequence:
    Chromosome: II; NC_003280.10 (3420663..3425533, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene FBA_2 domain-containing protein Neighboring gene Transmembrane protein Neighboring gene NEPrilysin metallopeptidase family Neighboring gene ncRNA Neighboring gene Tetratricopeptide repeat protein Neighboring gene ShKT domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Neprilysin-11
    NP_494538.1
    • Confirmed by transcript evidence
    NP_871928.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      3420663..3425533 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062137.6 → NP_494538.1  Neprilysin-11 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494538.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16796, Q8ITZ3
      Conserved Domains (2) summary
      cd08662
      Location:181 → 845
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:174 → 848
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]

    2. NM_182128.5 → NP_871928.1  Neprilysin-11 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871928.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16796
      Conserved Domains (1) summary
      cd08662
      Location:181 → 793
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O16796.2

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