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    tag-329 Cysteine proteinase [ Caenorhabditis elegans ]

    Gene ID: 183677, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tag-329
    Official Full Name
    Cysteine proteinase
    Primary source
    WormBase:WBGene00008231
    Locus tag
    CELE_C50F4.3
    See related
    AllianceGenome:WB:WBGene00008231
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be active in extracellular space and lysosome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tag-329 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (9534921..9536404)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene non-specific serine/threonine protein kinase Neighboring gene ATP-dependent 6-phosphofructokinase 2 Neighboring gene COMM domain-containing protein Neighboring gene Transcription termination factor 3, mitochondrial Neighboring gene Nudix hydrolase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lysosomal chloride transporter CLH-6 protects lysosome membrane integrity via cathepsin activation. Zhang Q, et al. J Cell Biol, 2023 Jun 5. PMID 37058288, Free PMC Article
    2. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. Sun Y, et al. Elife, 2020 Jun 2. PMID 32482227, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Cysteine proteinase
    NP_505458.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9534921..9536404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073057.5 → NP_505458.1  Cysteine proteinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505458.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18740
      Conserved Domains (2) summary
      smart00848
      Location:47 → 106
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      cd02248
      Location:141 → 368
      Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...
    Nucleotide Protein
    Heading Accession and Version

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