cysl-3 Cysteine synthase 3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cysl-3
Official Full Name: Cysteine synthase 3
Primary source: WormBase:WBGene00019962
Locus tag: CELE_R08E5.2
See related: AllianceGenome:WB:WBGene00019962
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables cysteine synthase activity. Involved in cysteine biosynthetic process from serine. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cysl-3 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 5

Sequence:: Chromosome: V; NC_003283.11 (3774536..3776136, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the role of CYSL-3 remains unclear although it exhibits sulfhydrylase activity in vitro.
Title: Biochemical properties of nematode O-acetylserine(thiol)lyase paralogs imply their distinct roles in hydrogen sulfide homeostasis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R08E5.2 (e-PCR)
- UniSTS:313280

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cysteine synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine synthase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cysteine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cysteine biosynthetic process from serine	IBA Inferred from Biological aspect of Ancestor more info
involved_in cysteine biosynthetic process from serine	IDA Inferred from Direct Assay more info	PubMed
involved_in cysteine biosynthetic process from serine	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Cysteine synthase 3

NP_504046.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

3774536..3776136 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_071645.7 → NP_504046.1 Cysteine synthase 3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_504046.1

Status: REVIEWED

UniProtKB/Swiss-Prot

H2L0J5, O01592, Q86NC6

Conserved Domains (2) summary

cd01561
Location:15 → 305

CBS_like; CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. ...

PLN02565
Location:2 → 321

PLN02565; cysteine synthase