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    top-1 DNA topoisomerase 1 [ Caenorhabditis elegans ]

    Gene ID: 266847, updated on 9-Dec-2024

    Summary

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    Official Symbol
    top-1
    Official Full Name
    DNA topoisomerase 1
    Primary source
    WormBase:WBGene00006595
    Locus tag
    CELE_M01E5.5
    See related
    AllianceGenome:WB:WBGene00006595
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables DNA topoisomerase type I (single strand cut, ATP-independent) activity. Predicted to be involved in DNA replication; DNA topological change; and chromosome segregation. Located in nucleolus and spindle pole centrosome. Is expressed in several structures, including excretory cell; germ line; gonad; neurons; and oocyte. Orthologous to human TOP1 (DNA topoisomerase I) and TOP1MT (DNA topoisomerase I mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See top-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (13292506..13297558)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene RNase NYN domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene tRNA-Lys Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential subcellular localization of DNA topoisomerase-1 isoforms and their roles during Caenorhabditis elegans development. Cha DS, et al. Gene Expr Patterns, 2012 May-Jun. PMID 22452997
    2. Regulation of gene expression, cellular localization, and in vivo function of Caenorhabditis elegans DNA topoisomerase I. Lee MH, et al. Genes Cells, 2001 Apr. PMID 11318873
    3. cDNA cloning, expression, and chromosomal localization of Caenorhabditis elegans DNA topoisomerase I. Kim J, et al. Eur J Biochem, 1996 Apr 15. PMID 8647074
    4. Transgene-mediated co-suppression of DNA topoisomerase-1 gene in Caenorhabditis elegans. Lee MH, et al. Int J Biochem Mol Biol, 2014. PMID 24955284, Free PMC Article
    5. Topoisomerases I and II facilitate condensin DC translocation to organize and repress X chromosomes in C. elegans. Morao AK, et al. Mol Cell, 2022 Nov 17. PMID 36302374, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA topoisomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA topoisomerase type I (single strand cut, ATP-independent) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA topoisomerase type I (single strand cut, ATP-independent) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA topoisomerase type I (single strand cut, ATP-independent) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA topological change IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA topological change IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA topoisomerase 1
    NP_001379240.1
    • Confirmed by transcript evidence
    NP_493337.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      13292506..13297558
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392963.1 → NP_001379240.1  DNA topoisomerase 1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      smart00435
      Location:330 → 703
      TOPEUc; DNA Topoisomerase I (eukaryota)
      cd03488
      Location:186 → 400
      Topoisomer_IB_N_htopoI_like; Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I. Topo I enzymes are divided into: topo type IA (bacterial) and type IB (eukaryotic). ...

    2. NM_060936.8 → NP_493337.1  DNA topoisomerase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493337.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O17965, O17966, Q27529
      Conserved Domains (4) summary
      smart00435
      Location:402 → 775
      TOPEUc; DNA Topoisomerase I (eukaryota)
      cd03488
      Location:258 → 472
      Topoisomer_IB_N_htopoI_like; Topoisomer_IB_N_htopoI_like : N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I. Topo I enzymes are divided into: topo type IA (bacterial) and type IB (eukaryotic). ...
      pfam01028
      Location:474 → 684
      Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core
      pfam14370
      Location:733 → 795
      Topo_C_assoc; C-terminal topoisomerase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O17966.1

    Gene LinkOut

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