fdgt-1 Facilitated glucose transporter protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: fdgt-1
Official Full Name: Facilitated glucose transporter protein 1
Primary source: WormBase:WBGene00019207
Locus tag: CELE_H17B01.1
See related: AllianceGenome:WB:WBGene00019207
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable hexose transmembrane transporter activity. Involved in D-glucose transmembrane transport. Predicted to be located in basolateral plasma membrane. Predicted to be active in membrane. Is expressed in intestinal cell and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in epilepsy (multiple); glucose metabolism disease (multiple); glycogen storage disease; myelomeningocele; and obesity. Orthologous to several human genes including SLC2A14 (solute carrier family 2 member 14) and SLC2A3 (solute carrier family 2 member 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See fdgt-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 10

Sequence:: Chromosome: II; NC_003280.10 (1504566..1509831)

Chromosome II - NC_003280.10 $Genomic Context describing neighboring genes$

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Caenorhabditis elegans homolog of human mitochondrial pyrimidine nucleotide transporter regulates glucose transport.
Title: The Caenorhabditis elegans homolog of human mitochondrial pyrimidine nucleotide transporter regulates glucose transport.
In C. elegans, FGT-1 is mainly a mammalian GLUT2-like intestinal glucose transporter and is involved in lipid metabolism.
Title: FGT-1 is a mammalian GLUT2-like facilitative glucose transporter in Caenorhabditis elegans whose malfunction induces fat accumulation in intestinal cells.
fgt-1 constitutes a common axis for the lifespan extending effects of nutrient restriction and reduced insulin-like peptide signalling.
Title: FGT-1 is the major glucose transporter in C. elegans and is central to aging pathways.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y51H7B_4.b (e-PCR)
- UniSTS:324395

H17B01.1a (e-PCR)
- UniSTS:322202

Y51H7B_4.a (e-PCR)
- UniSTS:323047

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables hexose transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in D-glucose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monosaccharide transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Facilitated glucose transporter protein 1

NP_493981.1

Confirmed by transcript evidence

NP_493982.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

1504566..1509831

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_061580.7 → NP_493981.1 Facilitated glucose transporter protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_493981.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O44827

Conserved Domains (2) summary

cd06174
Location:82 → 473

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:32 → 488

Sugar_tr; Sugar (and other) transporter
NM_061581.4 → NP_493982.1 Facilitated glucose transporter protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_493982.1

Status: REVIEWED

UniProtKB/Swiss-Prot

H2L0B9, O44827

Conserved Domains (2) summary

cd06174
Location:100 → 491

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:50 → 506

Sugar_tr; Sugar (and other) transporter