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    grd-1 Ground-like domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181300, updated on 9-Dec-2024

    Summary

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    Official Symbol
    grd-1
    Official Full Name
    Ground-like domain-containing protein
    Primary source
    WormBase:WBGene00001690
    Locus tag
    CELE_R08B4.1
    See related
    AllianceGenome:WB:WBGene00001690
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Acts upstream of or within nematode male tail mating organ morphogenesis. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Is expressed in rect_D; rect_VL; and rect_VR. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See grd-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    15
    Sequence:
    Chromosome: X; NC_003284.9 (11109440..11115887)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene AbiV family abortive infection protein;DUF2959 domain-containing protein Neighboring gene Transmembrane 9 superfamily member Neighboring gene Neuropeptide-Like Protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GRD-1/PTR-11, the C. elegans hedgehog/patched-like morphogen-receptor pair, modulates developmental rate. Emans SW, et al. Development, 2023 Dec 15. PMID 37982457, Free PMC Article
    2. Warthog and groundhog, novel families related to hedgehog. Bürglin TR. Curr Biol, 1996 Sep 1. PMID 8805384
    3. Homologs of the Hh signalling network in C. elegans. Bürglin TR, et al. WormBook, 2006 Jan 28. PMID 18050469, Free PMC Article
    4. C. elegans BLMP-1 controls apical epidermal cell morphology by repressing expression of mannosyltransferase bus-8 and molting signal mlt-8. Wu YZ, et al. Dev Biol, 2022 Jun. PMID 35367457
    5. Caenorhabditis elegans has scores of hedgehog-related genes: sequence and expression analysis. Aspöck G, et al. Genome Res, 1999 Oct. PMID 10523520

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GRD-1/PTR-11, the C. elegans hedgehog/patched-like morphogen-receptor pair, modulates developmental rate.
      Title: GRD-1/PTR-11, the C. elegans hedgehog/patched-like morphogen-receptor pair, modulates developmental rate.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    acts_upstream_of_or_within nematode male tail mating organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein autoprocessing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ground-like domain-containing protein
    NP_001024843.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      11109440..11115887
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029672.3 → NP_001024843.1  Ground-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024843.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21835
      Conserved Domains (3) summary
      cd00081
      Location:932 → 1080
      Hint; Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, ...
      pfam04155
      Location:436 → 518
      Ground-like; Ground-like domain
      pfam14179
      Location:571 → 638
      YppG; YppG-like protein
    Nucleotide Protein
    Heading Accession and Version

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