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    asb-2 ATP synthase F(0) complex subunit B2, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 180718, updated on 9-Dec-2024

    Summary

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    Official Symbol
    asb-2
    Official Full Name
    ATP synthase F(0) complex subunit B2, mitochondrial
    Primary source
    WormBase:WBGene00000207
    Locus tag
    CELE_F02E8.1
    See related
    AllianceGenome:WB:WBGene00000207
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable proton transmembrane transporter activity. Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in proton motive force-driven ATP synthesis. Predicted to be located in mitochondrial inner membrane. Predicted to be part of proton-transporting ATP synthase complex, coupling factor F(o). Is expressed in several structures, including gonad. Orthologous to human ATP5PB (ATP synthase peripheral stalk-membrane subunit b). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See asb-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    5
    Sequence:
    Chromosome: X; NC_003284.9 (4469766..4471476)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Autophagic-related protein 16.1 Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene NPC intracellular cholesterol transporter 1 homolog 1 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Targeting protein-protein interactions for parasite control. Taylor CM, et al. PLoS One, 2011 Apr 27. PMID 21556146, Free PMC Article
    2. ASB-1, a germline-specific isoform of mitochondrial ATP synthase b subunit, is required to maintain the rate of germline development in Caenorhabditis elegans. Kawasaki I, et al. Mech Dev, 2007 Mar. PMID 17223323
    3. ATP-2 interacts with the PLAT domain of LOV-1 and is involved in Caenorhabditis elegans polycystin signaling. Hu J, et al. Mol Biol Cell, 2005 Feb. PMID 15563610, Free PMC Article
    4. The mitochondrial permeability transition pore activates the mitochondrial unfolded protein response and promotes aging. Angeli S, et al. Elife, 2021 Sep 1. PMID 34467850, Free PMC Article
    5. C. elegans STI-1, the homolog of Sti1/Hop, is involved in aging and stress response. Song HO, et al. J Mol Biol, 2009 Jul 24. PMID 19467242

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables proton transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proton motive force-driven ATP synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton motive force-driven ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP synthase F(0) complex subunit B2, mitochondrial
    NP_508770.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      4469766..4471476
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076369.6 → NP_508770.1  ATP synthase F(0) complex subunit B2, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508770.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19126
      Conserved Domains (1) summary
      pfam05405
      Location:136 → 299
      Mt_ATP-synt_B; Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19126.1

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