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    mans-2 Mannosyl-oligosaccharide 1,2-alpha-mannosidase C52E4.5 [ Caenorhabditis elegans ]

    Gene ID: 179642, updated on 9-Dec-2024

    Summary

    Official Symbol
    mans-2
    Official Full Name
    Mannosyl-oligosaccharide 1,2-alpha-mannosidase C52E4.5
    Primary source
    WormBase:WBGene00008258
    Locus tag
    CELE_C52E4.5
    See related
    AllianceGenome:WB:WBGene00008258
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in ERAD pathway. Predicted to be located in membrane. Predicted to be active in Golgi membrane and endoplasmic reticulum. Orthologous to several human genes including MAN1A2 (mannosidase alpha class 1A member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See mans-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (11982901..11985484, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene 26S proteasome regulatory subunit 7 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in ERAD pathway  
    involved_in carbohydrate metabolic process  
    involved_in protein glycosylation  
    Component Evidence Code Pubs
    is_active_in Golgi membrane  
    is_active_in endoplasmic reticulum  
    located_in membrane  

    General protein information

    Preferred Names
    Mannosyl-oligosaccharide 1,2-alpha-mannosidase C52E4.5
    NP_001256389.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11982901..11985484 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269460.4 → NP_001256389.1  Mannosyl-oligosaccharide 1,2-alpha-mannosidase C52E4.5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256389.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1B6T6, Q18788
      Conserved Domains (1) summary
      pfam01532
      Location:146 → 587
      Glyco_hydro_47; Glycosyl hydrolase family 47
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