egl-20 Protein Wnt [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: egl-20
Official Full Name: Protein Wnt
Primary source: WormBase:WBGene00001188
Locus tag: CELE_W08D2.1
See related: AllianceGenome:WB:WBGene00001188
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables receptor tyrosine kinase binding activity. Involved in several processes, including neuron migration; positive regulation of axon guidance; and regulation of cell migration. Located in extracellular space. Is expressed in several structures, including hypodermis; muscle cell; neuroblasts; rectal epithelial cell; and somatic nervous system. Orthologous to human WNT16 (Wnt family member 16). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See egl-20 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 11

Sequence:: Chromosome: IV; NC_003282.8 (9812418..9815526, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PDI-1 performs this role in EGL-20/Wnt-producing epidermal cells to cell-non-autonomously control EGL-20/Wnt-dependent neuronal migration.
Title: A Protein Disulfide Isomerase Controls Neuronal Migration through Regulation of Wnt Secretion.
EGL-20 mediates an acute inhibition of anterior migration independently of BAR-1 and MAB-5, and a later, possible transcriptional response mediated by BAR-1 and MAB-5.
Title: EGL-20/Wnt and MAB-5/Hox Act Sequentially to Inhibit Anterior Migration of Neuroblasts in C. elegans.
our results strongly suggest that functions of at least four Wnts (lin-44, cwn-1, cwn-2, and egl-20) determine the polarity orientation of seam cells
Title: Multiple Wnts redundantly control polarity orientation in Caenorhabditis elegans epithelial stem cells.
CAM-1 interacts with and inhibits Egl-20, CWN-1 and MOM-2 during vulva morphogenesis.
Title: The C. elegans ROR receptor tyrosine kinase, CAM-1, non-autonomously inhibits the Wnt pathway.
The egl-20 signal provides a response to neuroblast migration asymmetry.
Title: Identification of genes that regulate a left-right asymmetric neuronal migration in Caenorhabditis elegans.
CAM-1 negatively regulates EGL-20
Title: The Caenorhabditis elegans Ror RTK CAM-1 inhibits EGL-20/Wnt signaling in cell migration.
findings show that the retromer, a multiprotein complex involved in intracellular protein trafficking, is required for long-range signaling of the Caenorhabditis elegans Wnt ortholog EGL-20
Title: Wnt gradient formation requires retromer function in Wnt-producing cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W08D2.1 (e-PCR)
- UniSTS:315193

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables receptor ligand activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables receptor tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in asymmetric cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitotic spindle orientation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in generation of neurons	IEA Inferred from Electronic Annotation more info
involved_in interneuron migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in left/right axis specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitochondrial unfolded protein response	IDA Inferred from Direct Assay more info	PubMed
involved_in motor neuron migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in motor neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of motor neuron migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuroblast migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of anterior/posterior axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of distal tip cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of motor neuron migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of sensory neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in programmed cell death involved in cell development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in programmed cell death involved in cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of vulval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sensory neuron migration	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: Protein Wnt

NP_001366963.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

9812418..9815526 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001380420.2 → NP_001366963.1 Protein Wnt [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G5EG05

Conserved Domains (1) summary

cl38924
Location:70 → 393

Wnt; Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family