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    aat-6 Amino acid transporter protein 6 [ Caenorhabditis elegans ]

    Gene ID: 188421, updated on 9-Dec-2024

    Summary

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    Official Symbol
    aat-6
    Official Full Name
    Amino acid transporter protein 6
    Primary source
    WormBase:WBGene00000007
    Locus tag
    CELE_T11F9.4
    See related
    AllianceGenome:WB:WBGene00000007
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables PDZ domain binding activity. Predicted to be involved in amino acid transmembrane transport. Located in apical plasma membrane. Is expressed in intestine. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See aat-6 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (11466842..11470663, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Zrt (ZRT), Irt- (IRT-) like Protein Transporter Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Zinc metalloproteinase nas-20 Neighboring gene Zinc metalloproteinase-like protein nas-21

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NRFL-1, the C. elegans NHERF orthologue, interacts with amino acid transporter 6 (AAT-6) for age-dependent maintenance of AAT-6 on the membrane. Hagiwara K, et al. PLoS One, 2012. PMID 22916205, Free PMC Article
    2. The Reproduction Rate of Peptide Transporter PEPT-1 Deficient C. elegans Is Dependent on Dietary Glutamate Supply. Spanier B, et al. Front Mol Biosci, 2018. PMID 30560135, Free PMC Article
    3. Functional characterization of Caenorhabditis elegans heteromeric amino acid transporters. Veljkovic E, et al. J Biol Chem, 2004 Feb 27. PMID 14668347
    4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables PDZ domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-alpha-amino acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Amino acid transporter protein 6
    NP_001123014.1
    • Confirmed by transcript evidence
    NP_505905.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11466842..11470663 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073504.5 → NP_505905.2  Amino acid transporter protein 6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505905.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B2D6M4, Q22397
      Conserved Domains (1) summary
      TIGR00911
      Location:18 → 482
      2A0308; L-type amino acid transporter

    2. NM_001129542.4 → NP_001123014.1  Amino acid transporter protein 6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001123014.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B2D6M4
      Conserved Domains (1) summary
      TIGR00911
      Location:8 → 472
      2A0308; L-type amino acid transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q22397.2

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