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    ckr-2 G-protein coupled receptors family 1 profile domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175341, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ckr-2
    Official Full Name
    G-protein coupled receptors family 1 profile domain-containing protein
    Primary source
    WormBase:WBGene00021439
    Locus tag
    CELE_Y39A3B.5
    See related
    AllianceGenome:WB:WBGene00021439
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables neuropeptide binding activity. Involved in determination of adult lifespan and neuropeptide signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in neurons. Human ortholog(s) of this gene implicated in obesity; pancreatic cancer; and panic disorder. Orthologous to several human genes including CCKAR (cholecystokinin A receptor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ckr-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    13
    Sequence:
    Chromosome: III; NC_003281.10 (2009299..2021595, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene tRNA Neighboring gene Ligand-Gated ion Channel Neighboring gene Peptidase M28 domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Glu Neighboring gene tRNA-Glu Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A pharmacological study of NLP-12 neuropeptide signaling in free-living and parasitic nematodes. Peeters L, et al. Peptides, 2012 Mar. PMID 22019590
    2. A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior. Ramachandran S, et al. Elife, 2021 Nov 12. PMID 34766905, Free PMC Article
    3. A neuropeptide-mediated stretch response links muscle contraction to changes in neurotransmitter release. Hu Z, et al. Neuron, 2011 Jul 14. PMID 21745640, Free PMC Article
    4. NLP-12 engages different UNC-13 proteins to potentiate tonic and evoked release. Hu Z, et al. J Neurosci, 2015 Jan 21. PMID 25609620, Free PMC Article
    5. Discovery of a cholecystokinin-gastrin-like signaling system in nematodes. Janssen T, et al. Endocrinology, 2008 Jun. PMID 18339709

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior.
      Title: A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neuropeptide binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables neuropeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptors family 1 profile domain-containing protein
    NP_001293648.1
    • Confirmed by transcript evidence
    NP_001367972.1
    • Confirmed by transcript evidence
    NP_001367973.1
    • Confirmed by transcript evidence
    NP_001367974.1
    • Confirmed by transcript evidence
    NP_001370897.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      2009299..2021595 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001381755.2 → NP_001367974.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4SNP8
      Conserved Domains (1) summary
      cd14993
      Location:61 → 411
      7tmA_CCKR-like; cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001384036.1 → NP_001370897.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      B2L044
      Conserved Domains (1) summary
      cd14993
      Location:19 → 369
      7tmA_CCKR-like; cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. NM_001381757.1 → NP_001367972.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECU0
      Conserved Domains (1) summary
      cd14993
      Location:19 → 466
      7tmA_CCKR-like; cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    4. NM_001381756.1 → NP_001367973.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4SNR2
      Conserved Domains (1) summary
      cd14993
      Location:61 → 508
      7tmA_CCKR-like; cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    5. NM_001306719.3 → NP_001293648.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293648.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B2L045
      Conserved Domains (1) summary
      cd14993
      Location:19 → 369
      7tmA_CCKR-like; cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein
    Heading Accession and Version

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