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    stn-2 PDZ domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181029, updated on 14-Nov-2024

    Summary

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    Official Symbol
    stn-2
    Official Full Name
    PDZ domain-containing protein
    Primary source
    WormBase:WBGene00017866
    Locus tag
    CELE_F27D9.8
    See related
    AllianceGenome:WB:WBGene00017866
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables cell adhesion molecule binding activity. Located in several cellular components, including cell body; neuron projection; and sarcomere. Is expressed in body wall musculature; enteric muscle; neurons; and vulva. Used to study Duchenne muscular dystrophy. Orthologous to several human genes including SNTG1 (syntrophin gamma 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See stn-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    15
    Sequence:
    Chromosome: X; NC_003284.9 (7676511..7680619, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene VWFA domain-containing protein Neighboring gene Peptidase M12B domain-containing protein Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Glu Neighboring gene Acetylcholine regulator unc-18

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. unc-44 Ankyrin and stn-2 gamma-syntrophin regulate sax-7 L1CAM function in maintaining neuronal positioning in Caenorhabditis elegans. Zhou S, et al. Genetics, 2008 Nov. PMID 18791240, Free PMC Article
    2. Neural integrity is maintained by dystrophin in C. elegans. Zhou S, et al. J Cell Biol, 2011 Jan 24. PMID 21242290, Free PMC Article
    3. The stn-1 syntrophin gene of C.elegans is functionally related to dystrophin and dystrobrevin. Grisoni K, et al. J Mol Biol, 2003 Oct 3. PMID 14499607
    4. "CRASH"ing with the worm: insights into L1CAM functions and mechanisms. Chen L, et al. Dev Dyn, 2010 May. PMID 20225255, Free PMC Article
    5. Predicting PDZ domain-peptide interactions from primary sequences. Chen JR, et al. Nat Biotechnol, 2008 Sep. PMID 18711339, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of dystrophin-associated glycoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sarcomere IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    PDZ domain-containing protein
    NP_001024610.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      7676511..7680619 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029439.5 → NP_001024610.1  PDZ domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024610.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5WRR6
      Conserved Domains (3) summary
      cd00992
      Location:63 → 147
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00169
      Location:304 → 386
      PH; PH domain
      pfam18012
      Location:204 → 261
      PH_17; PH domain
    Nucleotide Protein
    Heading Accession and Version

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