bpnt-1 3'(2'),5'-bisphosphate nucleotidase 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: bpnt-1
Official Full Name: 3'(2'),5'-bisphosphate nucleotidase 1
Primary source: WormBase:WBGene00044063
Locus tag: CELE_ZK430.2
See related: AllianceGenome:WB:WBGene00044063
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable 3'(2'),5'-bisphosphate nucleotidase activity. Involved in dauer exit; defense response to Gram-negative bacterium; and regulation of neuronal signal transduction. Is expressed in several structures, including amphid neurons; hypodermis; intestine; rectal gland cell; and tail. Orthologous to human BPNT1 (3'(2'), 5'-bisphosphate nucleotidase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See bpnt-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 4

Sequence:: Chromosome: II; NC_003280.10 (4420256..4422319)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

De-repression appears to be triggered such that more robust XRN2 perturbation, by elimination of both PAXT-1 and BPNT1, is less detrimental to worm viability than absence of PAXT-1 alone. Indeed, we find that two distinct XRN2 repression mechanisms are alleviated at different thresholds of XRN2 inactivation. Like more than 15% of C. elegans genes, xrn-2 occurs in an operon, and we identify additional
Title: XRN2 Autoregulation and Control of Polycistronic Gene Expresssion in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK430.2 (e-PCR)
- UniSTS:318745

ZK430.6 (e-PCR)
- UniSTS:317767

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 3'(2'),5'-bisphosphate nucleotidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in dauer exit	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuronal signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: 3'(2'),5'-bisphosphate nucleotidase 1

NP_494780.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

4420256..4422319

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_062379.7 → NP_494780.1 3'(2'),5'-bisphosphate nucleotidase 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_494780.1

Status: REVIEWED

UniProtKB/TrEMBL

Q23493

Conserved Domains (1) summary

cd01640
Location:11 → 303

IPPase; IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may ...