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    C54D10.10 BPTI/Kunitz inhibitor domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 183787, updated on 9-Dec-2024

    Summary

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    Official Symbol
    C54D10.10
    Official Full Name
    BPTI/Kunitz inhibitor domain-containing protein
    Primary source
    WormBase:WBGene00008304
    Locus tag
    CELE_C54D10.10
    See related
    AllianceGenome:WB:WBGene00008304
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Is expressed in nervous system; pharynx; reproductive system; and seam cell. Human ortholog(s) of this gene implicated in acute myeloid leukemia and retinal degeneration. Orthologous to human TFPI2 (tissue factor pathway inhibitor 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See C54D10.10 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (12448682..12450002, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Protein containing ALS2cr12 (ALS2CR12) signature Neighboring gene Protein containing ALS2cr12 (ALS2CR12) signature Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Suppressor of white apricot N-terminal domain-containing protein Neighboring gene Regulator of G-protein signaling egl-10

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    BPTI/Kunitz inhibitor domain-containing protein
    NP_506123.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12448682..12450002 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073722.5 → NP_506123.2  BPTI/Kunitz inhibitor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506123.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBJ3
      Conserved Domains (2) summary
      smart00131
      Location:158 → 213
      KU; BPTI/Kunitz family of serine protease inhibitors
      pfam00014
      Location:21 → 75
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    Nucleotide Protein
    Heading Accession and Version

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