tpp-2 Tripeptidyl-peptidase 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: tpp-2
Official Full Name: Tripeptidyl-peptidase 2
Primary source: WormBase:WBGene00017686
Locus tag: CELE_F21H12.6
See related: AllianceGenome:WB:WBGene00017686
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable tripeptidyl-peptidase activity. Involved in positive regulation of lipid storage. Predicted to be active in cytosol. Is expressed in intestine and nerve ring. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human TPP2 (tripeptidyl peptidase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See tpp-2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 9

Sequence:: Chromosome: II; NC_003280.10 (6092746..6097597, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F21H12.1 (e-PCR)
- UniSTS:309875

F21H12.6 (e-PCR)
- UniSTS:309878

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables aminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables tripeptidyl-peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tripeptidyl-peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Tripeptidyl-peptidase 2

NP_495221.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

6092746..6097597 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_062820.5 → NP_495221.1 Tripeptidyl-peptidase 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495221.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09541

Conserved Domains (3) summary

cd04857
Location:64 → 539

Peptidases_S8_Tripeptidyl_Aminopeptidase_II; Peptidase S8 family domain in Tripeptidyl aminopeptidases_II

pfam00082
Location:277 → 550

Peptidase_S8; Subtilase family

pfam12580
Location:832 → 1017

TPPII; Tripeptidyl peptidase II