mex-6 Zinc finger protein mex-6 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mex-6
Official Full Name: Zinc finger protein mex-6
Primary source: WormBase:WBGene00003231
Locus tag: CELE_AH6.5
See related: AllianceGenome:WB:WBGene00003231
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables mRNA 3'-UTR binding activity; protein domain specific binding activity; and protein kinase binding activity. Involved in regulation of protein localization. Located in P granule. Is expressed in AB; ABa; ABp; and germ line. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mex-6 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 7

Sequence:: Chromosome: II; NC_003280.10 (9524174..9526359)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Polo kinases, via their polo box domains, bind to and regulate the activity of two key polarity proteins, MEX-5 and MEX-6.
Title: Polo kinases regulate C. elegans embryonic polarity via binding to DYRK2-primed MEX-5 and MEX-6.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AH6.5 (e-PCR)
- UniSTS:307168

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of protein localization	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Zinc finger protein mex-6

NP_496043.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

9524174..9526359

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063642.7 → NP_496043.1 Zinc finger protein mex-6 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496043.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09436

Conserved Domains (3) summary

COG5063
Location:157 → 359

CTH1; CCCH-type Zn-finger protein [General function prediction only]

pfam00642
Location:318 → 345

zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

pfam03153
Location:53 → 245

TFIIA; Transcription factor IIA, alpha/beta subunit