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    npr-5 G-protein coupled receptors family 1 profile domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 190386, updated on 9-Dec-2024

    Summary

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    Official Symbol
    npr-5
    Official Full Name
    G-protein coupled receptors family 1 profile domain-containing protein
    Primary source
    WormBase:WBGene00021983
    Locus tag
    CELE_Y58G8A.4
    See related
    AllianceGenome:WB:WBGene00021983
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable neuropeptide binding activity and neuropeptide receptor activity. Involved in regulation of muscle contraction. Predicted to be located in membrane. Predicted to be active in neuron projection and plasma membrane. Is expressed in body wall musculature; chemosensory neurons; head neurons; and muscle cell. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human PRLHR (prolactin releasing hormone receptor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See npr-5 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (276985..281716, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Neurotransmitter-gated ion-channel ligand-binding domain-containing protein Neighboring gene Secreted protein Neighboring gene 'chromo' domain containing protein;Mediator complex subunit 6 Neighboring gene Protein phosphatase 1 regulatory subunit 21 N-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FMRFamide-like peptides encoded on the flp-18 precursor gene activate two isoforms of the orphan Caenorhabditis elegans G-protein-coupled receptor Y58G8A.4 heterologously expressed in mammalian cells. Kubiak TM, et al. Biopolymers, 2008. PMID 17879267
    2. Control of Locomotory Behavior of Caenorhabditis elegans by the Immunoglobulin Superfamily Protein RIG-3. Bhardwaj A, et al. Genetics, 2020 Jan. PMID 31740450, Free PMC Article
    3. Coordinated regulation of foraging and metabolism in C. elegans by RFamide neuropeptide signaling. Cohen M, et al. Cell Metab, 2009 Apr. PMID 19356718
    4. Co-transmission of neuropeptides and monoamines choreograph the C. elegans escape response. Florman JT, et al. PLoS Genet, 2022 Mar. PMID 35239681, Free PMC Article
    5. Kynurenic acid is a nutritional cue that enables behavioral plasticity. Lemieux GA, et al. Cell, 2015 Jan 15. PMID 25594177, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neuropeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neuropeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of muscle contraction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptors family 1 profile domain-containing protein
    NP_001024264.1
    • Confirmed by transcript evidence
    NP_001024265.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      276985..281716 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029093.5 → NP_001024264.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024264.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZY4
      Conserved Domains (1) summary
      cd15203
      Location:56 → 347
      7tmA_NPYR-like; neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001029094.5 → NP_001024265.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024265.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6F3C9
      Conserved Domains (1) summary
      cd15203
      Location:56 → 347
      7tmA_NPYR-like; neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein
    Heading Accession and Version

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