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    hst-3.1 Sulfotransferase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 185573, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hst-3.1
    Official Full Name
    Sulfotransferase domain-containing protein
    Primary source
    WormBase:WBGene00002030
    Locus tag
    CELE_F40H3.5
    See related
    AllianceGenome:WB:WBGene00002030
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Involved in heparan sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi lumen. Is expressed in several structures, including PDA; distal tip cell; head neurons; pharynx; and rectal epithelial cell. Orthologous to human HS3ST1 (heparan sulfate-glucosamine 3-sulfotransferase 1) and HS3ST5 (heparan sulfate-glucosamine 3-sulfotransferase 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hst-3.1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (6165653..6169256, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Bicarbonate transporter-like transmembrane domain-containing protein Neighboring gene Gamma-aminobutyric acid receptor exp-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distinct 3-O-sulfated heparan sulfate modification patterns are required for kal-1-dependent neurite branching in a context-dependent manner in Caenorhabditis elegans. Tecle E, et al. G3 (Bethesda), 2013 Mar. PMID 23451335, Free PMC Article
    2. Heparan sulphate sulphotransferase expression in mice and Caenorhabditis elegans. Turnbull J, et al. Biochem Soc Trans, 2003 Apr. PMID 12653634
    3. Direct visualization of specifically modified extracellular glycans in living animals. Attreed M, et al. Nat Methods, 2012 Apr 1. PMID 22466794, Free PMC Article
    4. The PAPS transporter PST-1 is required for heparan sulfation and is essential for viability and neural development in C. elegans. Bhattacharya R, et al. J Cell Sci, 2009 Dec 15. PMID 19920077, Free PMC Article
    5. Specific heparan sulfate modifications stabilize the synaptic organizer MADD-4/Punctin at Caenorhabditis elegans neuromuscular junctions. Cizeron M, et al. Genetics, 2021 Aug 9. PMID 33983408, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The C. elegans HS 3-O-sulfotransferases hst-3.1 and hst-3.2 are dispensable for viability.
      Title: Distinct 3-O-sulfated heparan sulfate modification patterns are required for kal-1-dependent neurite branching in a context-dependent manner in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heparan sulfate proteoglycan biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi lumen IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Sulfotransferase domain-containing protein
    NP_495230.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      6165653..6169256 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062829.3 → NP_495230.2  Sulfotransferase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495230.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A7UFE0, Q9TZK5
      Conserved Domains (1) summary
      cl21551
      Location:54 → 261
      Sulfotransfer_3; Sulfotransferase family
    Nucleotide Protein
    Heading Accession and Version

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