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    elp-1 Echinoderm microtubule-associated protein-like elp-1;HELP domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180358, updated on 9-Dec-2024

    Summary

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    Official Symbol
    elp-1
    Official Full Name
    Echinoderm microtubule-associated protein-like elp-1;HELP domain-containing protein
    Primary source
    WormBase:WBGene00001248
    Locus tag
    CELE_F38A6.2
    See related
    AllianceGenome:WB:WBGene00001248
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in microtubule cytoskeleton organization. Located in dendrite; neuromuscular junction; and neuronal cell body. Is expressed in several structures, including hypodermal cell; mechanosensory neurons; ray; spermatheca; and vulval muscle. Used to study Duchenne muscular dystrophy. Human ortholog(s) of this gene implicated in subcortical band heterotopia. Orthologous to several human genes including EML2 (EMAP like 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See elp-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    17
    Sequence:
    Chromosome: V; NC_003283.11 (20764971..20770161, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Defective pharyngeal development protein 4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DUF19 domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Hypoxia-inducible factor 1;PAS domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The C. elegans EMAP-like protein, ELP-1 is required for touch sensation and associates with microtubules and adhesion complexes. Hueston JL, et al. BMC Dev Biol, 2008 Nov 17. PMID 19014691, Free PMC Article
    2. Loss of dystrophin and the microtubule-binding protein ELP-1 causes progressive paralysis and death of adult C. elegans. Hueston JL, et al. Dev Dyn, 2009 Aug. PMID 19582871, Free PMC Article
    3. Conservation of the WD-repeat, microtubule-binding protein, EMAP, in sea urchins, humans, and the nematode C. elegans. Suprenant KA, et al. Dev Genes Evol, 2000 Jan. PMID 10603080
    4. Sensory neuron transcriptomes reveal complex neuron-specific function and regulation of mec-2/Stomatin splicing. Liang X, et al. Nucleic Acids Res, 2022 Mar 21. PMID 34875684, Free PMC Article
    5. Molecular structure of sarcomere-to-membrane attachment at M-Lines in C. elegans muscle. Qadota H, et al. J Biomed Biotechnol, 2010. PMID 20414365, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Echinoderm microtubule-associated protein-like elp-1;HELP domain-containing protein
    NP_001256950.1
    • Confirmed by transcript evidence
    NP_001256951.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      20764971..20770161 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001270021.4 → NP_001256950.1  Echinoderm microtubule-associated protein-like elp-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256950.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O45487
      Conserved Domains (5) summary
      COG2319
      Location:265 → 740
      WD40; WD40 repeat [General function prediction only]
      pfam03451
      Location:245 → 317
      HELP; HELP motif
      sd00039
      Location:409 → 450
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:326 → 570
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl19517
      Location:33 → 74
      PRK14127; cell division protein GpsB; Provisional

    2. NM_001270022.3 → NP_001256951.1  HELP domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256951.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4ALD8
      Conserved Domains (4) summary
      COG2319
      Location:352 → 779
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:406 → 447
      7WD40; WD40 repeat [structural motif]
      cd21931
      Location:34 → 76
      TD_EMAP-like; trimerization domain of the echinoderm microtubule-associated protein-like family
      pfam03451
      Location:246 → 315
      HELP; HELP motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O45487.1

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