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    cdh-5 Cadherin domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177671, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cdh-5
    Official Full Name
    Cadherin domain-containing protein
    Primary source
    WormBase:WBGene00000397
    Locus tag
    CELE_F08B4.2
    See related
    AllianceGenome:WB:WBGene00000397
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in cell-cell adhesion. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in Usher syndrome type 1D; Usher syndrome type 1F; and autosomal recessive nonsyndromic deafness 23. Orthologous to human PCDH15 (protocadherin related 15). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cdh-5 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    23
    Sequence:
    Chromosome: IV; NC_003282.8 (8668935..8676619)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene pseudo Neighboring gene Secreted protein Neighboring gene Neuropeptide-Like Protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in the Spliceosome Component prp-6 and Overexpression of cdh-5 Suppress Axon Guidance Defects of cdh-4 Mutants in Caenorhabditis elegans. Aburegeba Z, et al. Neurosci Insights, 2022. PMID 36090596, Free PMC Article
    2. The cadherin superfamily. Pettitt J. WormBook, 2005 Dec 29. PMID 18050421, Free PMC Article
    3. Cell adhesion receptors in C. elegans. Cox EA, et al. J Cell Sci, 2004 Apr 15. PMID 15090591
    4. Cadherin superfamily proteins in Caenorhabditis elegans and Drosophila melanogaster. Hill E, et al. J Mol Biol, 2001 Feb 2. PMID 11162110
    5. UNC-6 (netrin) orients the invasive membrane of the anchor cell in C. elegans. Ziel JW, et al. Nat Cell Biol, 2009 Feb. PMID 19098902, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cadherin domain-containing protein
    NP_001294026.1
    • Confirmed by transcript evidence
    NP_001343640.1
    • Confirmed by transcript evidence
    NP_001343703.1
    • Confirmed by transcript evidence
    NP_501487.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8668935..8676619
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001356929.4 → NP_001343640.1  Cadherin domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19194
      Conserved Domains (3) summary
      cd11304
      Location:812 → 906
      Cadherin_repeat; Cadherin tandem repeat domain
      PRK11633
      Location:596 → 701
      PRK11633; cell division protein DedD; Provisional
      cl26464
      Location:447 → 728
      Atrophin-1; Atrophin-1 family

    2. NM_001307097.4 → NP_001294026.1  Cadherin domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294026.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X5M8R9
      Conserved Domains (2) summary
      cd11304
      Location:669 → 763
      Cadherin_repeat; Cadherin tandem repeat domain
      NF033839
      Location:462 → 583
      PspC_subgroup_2; pneumococcal surface protein PspC, LPXTG-anchored form

    3. NM_069086.6 → NP_501487.1  Cadherin domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501487.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZC7
      Conserved Domains (1) summary
      cd11304
      Location:669 → 763
      Cadherin_repeat; Cadherin tandem repeat domain

    4. NM_001356930.4 → NP_001343703.1  Cadherin domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      X5M5L3
      Conserved Domains (3) summary
      cd11304
      Location:812 → 906
      Cadherin_repeat; Cadherin tandem repeat domain
      PRK11633
      Location:596 → 701
      PRK11633; cell division protein DedD; Provisional
      cl26464
      Location:447 → 728
      Atrophin-1; Atrophin-1 family
    Nucleotide Protein
    Heading Accession and Version

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