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    nhr-17 Nuclear Hormone Receptor family [ Caenorhabditis elegans ]

    Gene ID: 191719, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nhr-17
    Official Full Name
    Nuclear Hormone Receptor family
    Primary source
    WormBase:WBGene00003616
    Locus tag
    CELE_C02B4.2
    See related
    AllianceGenome:WB:WBGene00003616
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including excretory cell; intestine; nervous system; pharynx; and rectum. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nhr-17 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    9
    Sequence:
    Chromosome: X; NC_003284.9 (12663837..12667854, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Phage_int_SAM_5 domain-containing protein Neighboring gene tRNA-Ile Neighboring gene Neuropeptide-Like Protein Neighboring gene tRNA-Tyr Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The nuclear receptor superfamily has undergone extensive proliferation and diversification in nematodes. Sluder AE, et al. Genome Res, 1999 Feb. PMID 10022975
    2. A genome-wide map of conserved microRNA targets in C. elegans. Lall S, et al. Curr Biol, 2006 Mar 7. PMID 16458514
    3. Gene regulatory network inference in long-lived C. elegans reveals modular properties that are predictive of novel aging genes. Suriyalaksh M, et al. iScience, 2022 Jan 21. PMID 35036864, Free PMC Article
    4. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article
    5. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nuclear Hormone Receptor family
    NP_510115.1
    • Product from WormBase gene class nhr;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      12663837..12667854 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077714.6 → NP_510115.1  Nuclear Hormone Receptor family [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510115.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17589
      Conserved Domains (2) summary
      cd06157
      Location:182 → 360
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
      cd06960
      Location:31 → 105
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
    Nucleotide Protein
    Heading Accession and Version

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