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    haao-1 3-hydroxyanthranilate 3,4-dioxygenase [ Caenorhabditis elegans ]

    Gene ID: 179329, updated on 9-Dec-2024

    Summary

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    Official Symbol
    haao-1
    Official Full Name
    3-hydroxyanthranilate 3,4-dioxygenase
    Primary source
    WormBase:WBGene00010595
    Locus tag
    CELE_K06A4.5
    See related
    AllianceGenome:WB:WBGene00010595
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 3-hydroxyanthranilate 3,4-dioxygenase activity. Predicted to be involved in 'de novo' NAD biosynthetic process from tryptophan and quinolinate metabolic process. Predicted to be active in cytoplasm. Orthologous to human HAAO (3-hydroxyanthranilate 3,4-dioxygenase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See haao-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (9504910..9507118)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Gelsolin-like protein 1 Neighboring gene Sugar transporter SWEET Neighboring gene ncRNA Neighboring gene tRNA-Ala Neighboring gene 4-coumarate--CoA ligase Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation. van der Goot AT, et al. Proc Natl Acad Sci U S A, 2012 Sep 11. PMID 22927396, Free PMC Article
    2. On the benefits of the tryptophan metabolite 3-hydroxyanthranilic acid in Caenorhabditis elegans and mouse aging. Dang H, et al. Nat Commun, 2023 Dec 14. PMID 38097593, Free PMC Article
    3. Protein interaction mapping in C. elegans using proteins involved in vulval development. Walhout AJ, et al. Science, 2000 Jan 7. PMID 10615043
    4. C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression. Reboul J, et al. Nat Genet, 2003 May. PMID 12679813
    5. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 3-hydroxyanthranilate 3,4-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-hydroxyanthranilate 3,4-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferrous iron binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' NAD biosynthetic process from tryptophan IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 'de novo' NAD biosynthetic process from tryptophan IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in NAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in anthranilate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyridine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in quinolinate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in quinolinate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tryptophan catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    3-hydroxyanthranilate 3,4-dioxygenase
    NP_505450.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9504910..9507118
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073049.2 → NP_505450.1  3-hydroxyanthranilate 3,4-dioxygenase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505450.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19341, Q21258
      Conserved Domains (1) summary
      pfam06052
      Location:1 → 151
      3-HAO; 3-hydroxyanthranilic acid dioxygenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19341.2

    Gene LinkOut

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