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    srp-2 Serpin domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178586, updated on 27-Dec-2024

    Summary

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    Official Symbol
    srp-2
    Official Full Name
    Serpin domain-containing protein
    Primary source
    WormBase:WBGene00005643
    Locus tag
    CELE_C05E4.1
    See related
    AllianceGenome:WB:WBGene00005643
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables cysteine-type endopeptidase inhibitor activity and serine-type endopeptidase inhibitor activity. Predicted to be active in extracellular space. Is expressed in several structures, including anal sphincter muscle; cuticle; eggshell; epithelial cell; and phasmid neurons. Used to study familial encephalopathy with neuroserpin inclusion bodies. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); liver disease (multiple); lung disease (multiple); neurodegenerative disease (multiple); and retinal vascular disease (multiple). Orthologous to several human genes including SERPINI1 (serpin family I member 1) and SERPINI2 (serpin family I member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See srp-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (762817..764590)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Seven TM Receptor Neighboring gene F-box domain-containing protein Neighboring gene Ovule protein Neighboring gene Seven TM Receptor Neighboring gene Stress-induced-phosphoprotein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The aggregation-prone intracellular serpin SRP-2 fails to transit the ER in Caenorhabditis elegans. Silverman RM, et al. Genetics, 2015 May. PMID 25786854, Free PMC Article
    2. A novel interaction between aging and ER overload in a protein conformational dementia. Schipanski A, et al. Genetics, 2013 Mar. PMID 23335331, Free PMC Article
    3. Selective conservation of the RSL-encoding, proteinase inhibitory-type, clade L serpins in Caenorhabditis species. Luke CJ, et al. Front Biosci, 2006 Jan 1. PMID 16146754
    4. SRP-2 is a cross-class inhibitor that participates in postembryonic development of the nematode Caenorhabditis elegans: initial characterization of the clade L serpins. Pak SC, et al. J Biol Chem, 2004 Apr 9. PMID 14739286
    5. Hexosamine pathway metabolites enhance protein quality control and prolong life. Denzel MS, et al. Cell, 2014 Mar 13. PMID 24630720

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SRP-2 is neither an ortholog nor a functional homolog of neuroserpin.
      Title: The aggregation-prone intracellular serpin SRP-2 fails to transit the ER in Caenorhabditis elegans.
    2. SRP-2 is a cross-class inhibitor that participates in postembryonic development of the nematode
      Title: SRP-2 is a cross-class inhibitor that participates in postembryonic development of the nematode Caenorhabditis elegans: initial characterization of the clade L serpins.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Serpin domain-containing protein
    NP_503318.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      762817..764590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070917.9 → NP_503318.1  Serpin domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503318.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17365, Q6QUR0
      Conserved Domains (1) summary
      cd19581
      Location:7 → 358
      serpinL_nematode; serpin family L, serpin family proteins from nematodes
    Nucleotide Protein
    Heading Accession and Version

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