hpd-1 4-hydroxyphenylpyruvate dioxygenase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hpd-1
Official Full Name: 4-hydroxyphenylpyruvate dioxygenase
Primary source: WormBase:WBGene00001993
Locus tag: CELE_T21C12.2
See related: AllianceGenome:WB:WBGene00001993
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable 4-hydroxyphenylpyruvate dioxygenase activity. Predicted to be involved in tyrosine catabolic process. Predicted to be active in Golgi membrane and endoplasmic reticulum membrane. Is expressed in hypodermis and intestine. Human ortholog(s) of this gene implicated in hawkinsinuria and tyrosinemia type III. Orthologous to human HPD (4-hydroxyphenylpyruvate dioxygenase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hpd-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 3

Sequence:: Chromosome: III; NC_003281.10 (10535526..10537680)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T21C12.2 (e-PCR)
- UniSTS:315043

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 4-hydroxyphenylpyruvate dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 4-hydroxyphenylpyruvate dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables 4-hydroxyphenylpyruvate dioxygenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-phenylalanine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in aromatic amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in tyrosine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in tyrosine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in tyrosine catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 4-hydroxyphenylpyruvate dioxygenase

NP_001369878.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

10535526..10537680

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001382982.2 → NP_001369878.1 4-hydroxyphenylpyruvate dioxygenase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22633

Conserved Domains (1) summary

TIGR01263
Location:17 → 382

4HPPD; 4-hydroxyphenylpyruvate dioxygenase