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    gmd-2 GDP-mannose 4,6 dehydratase 2 [ Caenorhabditis elegans ]

    Gene ID: 186416, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gmd-2
    Official Full Name
    GDP-mannose 4,6 dehydratase 2
    Primary source
    WormBase:WBGene00010166
    Locus tag
    CELE_F56H6.5
    See related
    AllianceGenome:WB:WBGene00010166
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables GDP-mannose 4,6-dehydratase activity. Involved in GDP-L-fucose biosynthetic process and GDP-mannose metabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in open-angle glaucoma. Orthologous to human GMDS (GDP-mannose 4,6-dehydratase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gmd-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (12292202..12293936, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DUF268 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Carbohydrate sulfotransferase Neighboring gene B3GNT1, Beta-1,3-N-acetylGucosamiNylTransferase 1, homolog Neighboring gene Glycosyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reconstitution in vitro of the GDP-fucose biosynthetic pathways of Caenorhabditis elegans and Drosophila melanogaster. Rhomberg S, et al. FEBS J, 2006 May. PMID 16650000
    2. Pmr-1 gene affects susceptibility of Caenorhabditis elegans to Staphylococcus aureus infection through glycosylation and stress response pathways' alterations. Schifano E, et al. Virulence, 2019 Dec. PMID 31771413, Free PMC Article
    3. WormQTL2: an interactive platform for systems genetics in Caenorhabditis elegans. Snoek BL, et al. Database (Oxford), 2020 Jan 1. PMID 31960906, Free PMC Article
    4. Carbohydrates and glycosylation. Berninsone PM. WormBook, 2006 Dec 18. PMID 18050430, Free PMC Article
    5. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cloning, purification and charactrization of gmd-2
      Title: Reconstitution in vitro of the GDP-fucose biosynthetic pathways of Caenorhabditis elegans and Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GDP-mannose 4,6-dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GDP-mannose 4,6-dehydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GDP-mannose 4,6-dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' GDP-L-fucose biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 'de novo' GDP-L-fucose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GDP-L-fucose biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in GDP-L-fucose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GDP-mannose metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in GDP-mannose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GDP-mannose 4,6 dehydratase 2
    NP_493106.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      12292202..12293936 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060705.3 → NP_493106.1  GDP-mannose 4,6 dehydratase 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493106.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O45583, Q1H8X4
      Conserved Domains (2) summary
      COG1089
      Location:32 → 377
      Gmd; GDP-D-mannose dehydratase [Cell wall/membrane/envelope biogenesis]
      pfam16363
      Location:37 → 368
      GDP_Man_Dehyd; GDP-mannose 4,6 dehydratase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O45583.1

    Gene LinkOut

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