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    glt-3 Putative sodium-dependent excitatory amino acid transporter glt-3 [ Caenorhabditis elegans ]

    Gene ID: 177882, updated on 9-Dec-2024

    Summary

    Official Symbol
    glt-3
    Official Full Name
    Putative sodium-dependent excitatory amino acid transporter glt-3
    Primary source
    WormBase:WBGene00001621
    Locus tag
    CELE_K08F4.4
    See related
    AllianceGenome:WB:WBGene00001621
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable L-glutamate transmembrane transporter activity; glutamate:sodium symporter activity; and neutral L-amino acid transmembrane transporter activity. Predicted to be involved in L-glutamate transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in excretory cell and pharynx. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 41. Orthologous to human SLC1A2 (solute carrier family 1 member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See glt-3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (10130257..10133283)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Translocon-associated protein subunit beta Neighboring gene Uncharacterized protein Neighboring gene Ovule protein

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables L-glutamate transmembrane transporter activity  
    enables glutamate:sodium symporter activity  
    enables neutral L-amino acid transmembrane transporter activity  
    enables symporter activity  
    Component Evidence Code Pubs
    located_in membrane  
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    Putative sodium-dependent excitatory amino acid transporter glt-3
    NP_501844.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      10130257..10133283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069443.6 → NP_501844.1  Putative sodium-dependent excitatory amino acid transporter glt-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501844.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21353
      Conserved Domains (1) summary
      pfam00375
      Location:32 → 441
      SDF; Sodium:dicarboxylate symporter family
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