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    npr-33 G-protein coupled receptors family 1 profile domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 185141, updated on 9-Dec-2024

    Summary

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    Official Symbol
    npr-33
    Official Full Name
    G-protein coupled receptors family 1 profile domain-containing protein
    Primary source
    WormBase:WBGene00009278
    Locus tag
    CELE_F31B9.1
    See related
    AllianceGenome:WB:WBGene00009278
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); chronic kidney disease (multiple); glomerulonephritis (multiple); lung disease (multiple); and neurodegenerative disease (multiple). Orthologous to several human genes including GPR15 (G protein-coupled receptor 15); GPR25 (G protein-coupled receptor 25); and AGTR1 (angiotensin II receptor type 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See npr-33 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    7
    Sequence:
    Chromosome: X; NC_003284.9 (15910628..15914468)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene C6 domain-containing protein Neighboring gene C6 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptors family 1 profile domain-containing protein
    NP_510612.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      15910628..15914468
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078211.2 → NP_510612.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510612.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O62189
      Conserved Domains (1) summary
      cd00637
      Location:62 → 332
      7tm_classA_rhodopsin-like; rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein
    Heading Accession and Version

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