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    cyn-16 Spliceosome-associated protein CWC27 homolog [ Caenorhabditis elegans ]

    Gene ID: 174843, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cyn-16
    Official Full Name
    Spliceosome-associated protein CWC27 homolog
    Primary source
    WormBase:WBGene00000892
    Locus tag
    CELE_Y17G7B.9
    See related
    AllianceGenome:WB:WBGene00000892
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to be located in nucleus. Predicted to be part of catalytic step 2 spliceosome. Is expressed in intestine and ventral cord neurons. Orthologous to human CWC27 (CWC27 spliceosome associated cyclophilin). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cyn-16 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (12028128..12036742, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Globin domain-containing protein Neighboring gene ncRNA Neighboring gene RNA exonuclease 4 Neighboring gene F-box domain-containing protein Neighboring gene Triosephosphate isomerase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel cyclophilin from parasitic and free-living nematodes with a unique substrate- and drug-binding domain. Ma D, et al. J Biol Chem, 2002 Apr 26. PMID 11847225
    2. Identification and comparative analysis of the peptidyl-prolyl cis/trans isomerase repertoires of H. sapiens, D. melanogaster, C. elegans, S. cerevisiae and Sz. pombe. Pemberton TJ, et al. Comp Funct Genomics, 2005. PMID 18629211, Free PMC Article
    3. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables peptidyl-prolyl cis-trans isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein peptidyl-prolyl isomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Spliceosome-associated protein CWC27 homolog
    NP_496562.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      12028128..12036742 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064161.7 → NP_496562.3  Spliceosome-associated protein CWC27 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496562.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XXI7
      Conserved Domains (2) summary
      PRK14906
      Location:258 → 353
      PRK14906; DNA-directed RNA polymerase subunit beta'
      cd01925
      Location:8 → 175
      cyclophilin_CeCYP16-like; cyclophilin-type peptidylprolyl cis- trans isomerase) (PPIase) domain similar to Caenorhabditis elegans cyclophilin 16. C. elegans CeCYP-16, compared to the archetypal cyclophilin Human cyclophilin A has, a reduced peptidylprolyl cis- trans isomerase ...
    Nucleotide Protein
    Heading Accession and Version

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