gpdh-3 putative glycerol-3-phosphate dehydrogenase, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gpdh-3
Official Full Name: putative glycerol-3-phosphate dehydrogenase, mitochondrial
Primary source: WormBase:WBGene00012031
Locus tag: CELE_T25G3.4
See related: AllianceGenome:WB:WBGene00012031
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable calcium ion binding activity and glycerol-3-phosphate dehydrogenase (quinone) activity. Predicted to be involved in glycerol catabolic process and glycerol-3-phosphate metabolic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human GPD2 (glycerol-3-phosphate dehydrogenase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See gpdh-3 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 6

Sequence:: Chromosome: I; NC_003279.8 (7564584..7567719)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T25G3.4 (e-PCR)
- UniSTS:308119

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables glycerol-3-phosphate dehydrogenase (quinone) activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glycerol catabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycerol-3-phosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in organophosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphate-containing compound metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative glycerol-3-phosphate dehydrogenase, mitochondrial

NP_492115.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

7564584..7567719

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059714.7 → NP_492115.1 putative glycerol-3-phosphate dehydrogenase, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492115.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P90795, Q22793

Conserved Domains (4) summary

PLN02464
Location:46 → 602

PLN02464; glycerol-3-phosphate dehydrogenase

cd00051
Location:628 → 685

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam13499
Location:629 → 689

EF-hand_7; EF-hand domain pair

pfam16901
Location:464 → 590

DAO_C; C-terminal domain of alpha-glycerophosphate oxidase